| 8/30/2018 | Wake Forest | 23 | at | Tulane | 17 | OT | @ AAC | |
| 8/31/2018 | Army | 14 | at | Duke | 34 | Ind | ||
| Syracuse | 55 | at | Western Michigan | 42 | @ MAC | |||
| 9/1/2018 | Louisville | 14 | vs | Alabama | 51 | Orlando FL | vs SEC | |
| Massachusetts | 21 | at | Boston College | 55 | Ind | |||
| North Carolina | 17 | at | California | 24 | @ P12 | |||
| Furman | 7 | at | Clemson | 48 | SoCon (1AA) | |||
| Alcorn State | 0 | at | Georgia Tech | 41 | SWAC (1AA) | |||
| James Madison | 13 | at | North Carolina State | 24 | CAAF (1AA) | |||
| Albany NY | 7 | at | Pittsburgh | 33 | CAAF (1AA) | |||
| Richmond | 13 | at | Virginia | 42 | CAAF (1AA) | |||
| 9/2/2018 | Miami-Florida | 17 | vs | LSU | 33 | Arlington TX | vs SEC | |
| 9/3/2018 | Virginia Tech | 24 | at | Florida State | 3 | |||
| 9/8/2018 | Holy Cross | 14 | at | Boston College | 62 | Pat (1AA) | ||
| North Carolina | 19 | at | East Carolina | 41 | @ AAC | |||
| Samford | 26 | at | Florida State | 36 | SoCon (1AA) | |||
| Virginia | 16 | at | Indiana | 20 | @ B10 | |||
| Indiana State | 7 | at | Louisville | 31 | MVC (1AA) | |||
| Savannah State | 0 | at | Miami-Florida | 77 | MEAC (1AA) | |||
| Georgia State | 7 | at | North Carolina State | 41 | SBC | |||
| Duke | 21 | at | Northwestern | 7 | @ B10 | |||
| Penn State | 51 | at | Pittsburgh | 6 | B10 | |||
| Georgia Tech | 38 | at | South Florida | 49 | @ AAC | |||
| Wagner | 10 | at | Syracuse | 62 | NE (1AA) | |||
| Clemson | 28 | at | Texas A&M | 26 | @ SEC | |||
| William & Mary | 17 | at | Virginia Tech | 62 | CAAF (1AA) | |||
| Towson | 20 | at | Wake Forest | 51 | CAAF (1AA) | |||
| 9/13/2018 | Boston College | 41 | at | Wake Forest | 34 | |||
| 9/15/2018 | Duke | 40 | at | Baylor | 27 | @ B12 | ||
| Georgia Southern | 7 | at | Clemson | 38 | SBC | |||
| Western Kentucky | 17 | at | Louisville | 20 | CUSA | |||
| UCF | vs | North Carolina | CCD | vs AAC | ||||
| West Virginia | vs | North Carolina State | CCD | vs B12 | ||||
| Georgia Tech | 19 | at | Pittsburgh | 24 | ||||
| Florida State | 7 | at | Syracuse | 30 | ||||
| Miami-Florida | 49 | at | Toledo | 24 | @ MAC | |||
| Ohio | 31 | vs | Virginia | 45 | Nashville TN | vs MAC | ||
| East Carolina | vs | Virginia Tech | CCD | vs AAC | ||||
| 9/22/2018 | North Carolina Central | 13 | at | Duke | 55 | MEAC (1AA) | ||
| Northern Illinois | 19 | at | Florida State | 37 | MAC | |||
| Clemson | 49 | at | Georgia Tech | 21 | ||||
| North Carolina State | 37 | at | Marshall | 20 | @ CUSA | |||
| Florida Intl | 17 | at | Miami-Florida | 31 | CUSA | |||
| Pittsburgh | 35 | at | North Carolina | 38 | ||||
| Virginia Tech | 35 | at | Old Dominion | 49 | @ CUSA | |||
| Boston College | 13 | at | Purdue | 30 | @ B10 | |||
| Connecticut | 21 | at | Syracuse | 51 | AAC | |||
| Louisville | 3 | at | Virginia | 27 | ||||
| Notre Dame | 56 | at | Wake Forest | 27 | ND | |||
| 9/27/2018 | North Carolina | 10 | at | Miami-Florida | 47 | |||
| 9/29/2018 | Temple | 35 | at | Boston College | 45 | AAC | ||
| Pittsburgh | 14 | at | UCF | 45 | @ AAC | |||
| Syracuse | 23 | at | Clemson | 27 | ||||
| Virginia Tech | 31 | at | Duke | 14 | ||||
| Bowling Green | 17 | at | Georgia Tech | 63 | MAC | |||
| Florida State | 28 | at | Louisville | 24 | ||||
| Virginia | 21 | at | North Carolina State | 35 | ||||
| Rice | 24 | at | Wake Forest | 56 | CUSA | |||
| 10/5/2018 | Georgia Tech | 66 | at | Louisville | 31 | |||
| 10/6/2018 | Florida State | 27 | at | Miami-Florida | 28 | |||
| Boston College | 23 | at | North Carolina State | 28 | ||||
| Syracuse | 37 | at | Pittsburgh | 44 | OT | |||
| Notre Dame | 45 | at | Virginia Tech | 23 | ND | |||
| Clemson | 63 | at | Wake Forest | 3 | ||||
| 10/13/2018 | Louisville | 20 | at | Boston College | 38 | |||
| Duke | 28 | at | Georgia Tech | 14 | ||||
| Virginia Tech | 22 | at | North Carolina | 19 | ||||
| Pittsburgh | 14 | at | Notre Dame | 19 | @ ND | |||
| Miami-Florida | 13 | at | Virginia | 16 | ||||
| 10/20/2018 | North Carolina State | 7 | at | Clemson | 41 | |||
| Virginia | 28 | at | Duke | 14 | ||||
| Wake Forest | 17 | at | Florida State | 38 | ||||
| North Carolina | 37 | at | Syracuse | 40 | 2OT | |||
| 10/25/2018 | Georgia Tech | 49 | at | Virginia Tech | 28 | |||
| 10/26/2018 | Miami-Florida | 14 | at | Boston College | 27 | |||
| 10/27/2018 | Clemson | 59 | at | Florida State | 10 | |||
| Wake Forest | 56 | at | Louisville | 35 | ||||
| Duke | 45 | at | Pittsburgh | 54 | ||||
| North Carolina State | 41 | at | Syracuse | 51 | ||||
| North Carolina | 21 | at | Virginia | 31 | ||||
| 11/2/2018 | Pittsburgh | 23 | at | Virginia | 13 | |||
| 11/3/2018 | Louisville | 16 | at | Clemson | 77 | |||
| Duke | 20 | at | Miami-Florida | 12 | ||||
| Georgia Tech | 38 | at | North Carolina | 28 | ||||
| Florida State | 28 | at | North Carolina State | 47 | ||||
| Boston College | 31 | at | Virginia Tech | 21 | ||||
| Syracuse | 41 | at | Wake Forest | 24 | ||||
| 11/8/2018 | Wake Forest | 27 | at | North Carolina State | 23 | |||
| 11/9/2018 | Louisville | 23 | at | Syracuse | 54 | |||
| 11/10/2018 | Clemson | 27 | at | Boston College | 7 | |||
| North Carolina | 35 | at | Duke | 42 | ||||
| Miami-Florida | 21 | at | Georgia Tech | 27 | ||||
| Florida State | 13 | at | Notre Dame | 42 | @ ND | |||
| Virginia Tech | 22 | at | Pittsburgh | 52 | ||||
| Liberty | 24 | at | Virginia | 45 | Ind | |||
| 11/17/2018 | Duke | 6 | at | Clemson | 35 | |||
| Boston College | 21 | at | Florida State | 22 | ||||
| Virginia | 27 | at | Georgia Tech | 30 | OT | |||
| North Carolina State | 52 | at | Louisville | 10 | ||||
| Western Carolina | 26 | at | North Carolina | 49 | SoCon (1AA) | |||
| Syracuse | 3 | vs | Notre Dame | 36 | Bronx NY | vs ND | ||
| Miami-Florida | 38 | at | Virginia Tech | 14 | ||||
| Pittsburgh | 34 | at | Wake Forest | 13 | ||||
| 11/23/2018 | Virginia | 31 | at | Virginia Tech | 34 | |||
| 11/24/2018 | Syracuse | 42 | at | Boston College | 21 | |||
| South Carolina | 35 | at | Clemson | 56 | SEC | |||
| Wake Forest | 59 | at | Duke | 7 | ||||
| Florida | 41 | at | Florida State | 14 | SEC | |||
| Georgia Tech | 21 | at | Georgia | 45 | @ SEC | |||
| Kentucky | 56 | at | Louisville | 10 | SEC | |||
| Pittsburgh | 3 | at | Miami-Florida | 24 | ||||
| North Carolina State | 34 | at | North Carolina | 28 | OT | |||
| 12/1/2018 | East Carolina | 3 | at | North Carolina State | 58 | AAC | ||
| Clemson | 42 | vs | Pittsburgh | 10 | ACC Championship Charlotte NC | |||
| Marshall | 20 | at | Virginia Tech | 41 | CUSA | |||
| 12/22/2018 | Memphis | 34 | vs | Wake Forest | 37 | BIRMINGHAM BOWL - Birmingham AL | vs AAC | |
| 12/26/2018 | Boston College | vs | Boise State | SERVPRO FIRST RESPONDER BOWL - Dallas TX (CCD) | vs MW | |||
| Minnesota | 34 | vs | Georgia Tech | 10 | QUICK LANE BOWL - Detroit MI | vs B10 | ||
| 12/27/2018 | Temple | 27 | vs | Duke | 56 | WALK-ON'S INDEPENDENCE BOWL - Shrevepoint LA | vs AAC | |
| Miami-Florida | 3 | vs | Wisconsin | 35 | NEW ERA PINSTRIPE BOWL - New York NY | vs B10 | ||
| 12/28/2018 | West Virginia | 18 | vs | Syracuse | 34 | CAMPING WORLD BOWL - Orlando FL | vs B12 | |
| 12/29/2018 | Notre Dame | 3 | vs | Clemson | 30 | 1A Semifinal Arlington TX | vs ND | |
| South Carolina | 0 | vs | Virginia | 28 | BELK BOWL - Charlotte NC | vs SEC | ||
| 12/31/2018 | Stanford | 14 | vs | Pittsburgh | 13 | HYUNDAI SUN BOWL - El Paso TX | vs P12 | |
| North Carolina State | 13 | vs | Texas A&M | 52 | TAXSLAYER GATOR BOWL - Jacksonville FL | vs SEC | ||
| Cincinnati | 35 | vs | Virginia Tech | 31 | MILITARY BOWL PRESENTED BY NORTHROP GRUMMAN - Annapolis MD | vs AAC | ||
| 1/7/2019 | Clemson | 44 | vs | Alabama | 16 | 1A Championship - Santa Clara CA | vs SEC |