| 8/30/2018 | Shorter (0-11) | 9 | at | Samford | 66 | GSC (D2) | ||
| 9/8/2018 | Samford | 26 | at | Florida State (5-7) | 36 | at ACC | ||
| 9/15/2018 | Mercer (5-6,4-4) | 30 | at | Samford | 24 | |||
| 9/22/2018 | Samford | 20 | at | Chattanooga (6-5,4-4) | 27 | |||
| 9/29/2018 | Samford | 10 | at | Kennesaw St (11-2) | 24 | at BigS | ||
| 10/6/2018 | Western Carolina (3-8,1-7) | 28 | at | Samford | 66 | |||
| 10/13/2018 | VMI (1-10,0-8) | 22 | at | Samford | 73 | |||
| 10/20/2018 | Samford | 38 | at | Furman (6-4,6-2) | 25 | |||
| 11/3/2018 | Wofford (9-4,6-2) | 20 | at | Samford | 35 | |||
| 11/10/2018 | Samford | 27 | at | The Citadel (5-6,4-4) | 42 | |||
| 11/17/2018 | Samford | 38 | at | East Tennessee St (8-4,6-2) | 27 |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 5-6 | 54-61 | |
| Points Scored: | 26.36 | 27.46 | 1.10 |
| Points Allowed: | 38.45 | 30.08 | 8.37 |
| Margin: | -12.09 | -2.62 | 9.47 |
| Total Points: | 64.81 | 57.54 | 7.27 |