| 9/1/2018 | Howard (4-6) | 32 | at | Ohio | 38 | MEAC (1AA) | ||
| 9/15/2018 | Ohio | 31 | vs | Virginia (8-5) | 45 | Nashville TN | vs ACC | |
| 9/22/2018 | Ohio | 30 | at | Cincinnati (11-2) | 34 | at AAC | ||
| 9/29/2018 | Massachusetts (4-8) | 42 | at | Ohio | 58 | Ind | ||
| 10/6/2018 | Ohio | 27 | at | Kent State (2-10,1-7) | 26 | |||
| 10/13/2018 | Ohio | 21 | at | Northern Illinois (8-6,7-2) | 24 | |||
| 10/20/2018 | Bowling Green (3-9,2-6) | 14 | at | Ohio | 49 | |||
| 10/25/2018 | Ball State (4-8,3-5) | 14 | at | Ohio | 52 | |||
| 11/1/2018 | Ohio | 59 | at | Western Michigan (7-6,5-3) | 14 | |||
| 11/7/2018 | Ohio | 28 | at | Miami-Ohio (6-6,6-2) | 30 | |||
| 11/14/2018 | Buffalo (10-4,7-2) | 17 | at | Ohio | 52 | |||
| 11/23/2018 | Akron (4-8,2-6) | 28 | at | Ohio | 49 | |||
| 12/19/2018 | San Diego State (7-6) | 0 | vs | Ohio | 27 | DXL FRISCO BOWL - Frisco TX | MW |
| vs Ohio | vs Other Opponents | Ohio compared to OOs | |
| Record: | 4-9 | 74-75 | |
| Points Scored: | 24.62 | 27.63 | 3.01 |
| Points Allowed: | 40.08 | 28.04 | 12.04 |
| Margin: | -15.46 | -0.41 | 15.05 |
| Total Points: | 64.70 | 55.67 | 9.03 |