| 9/1/2018 | Old Dominion | 10 | at | Liberty (6-6) | 52 | at Ind | ||
| 9/8/2018 | Florida Intl (9-4,6-2) | 28 | at | Old Dominion | 20 | |||
| 9/13/2018 | Old Dominion | 25 | at | UNC-Charlotte (5-7,4-4) | 28 | |||
| 9/22/2018 | Virginia Tech (6-7) | 35 | at | Old Dominion | 49 | ACC | ||
| 9/29/2018 | Old Dominion | 35 | at | East Carolina (3-9) | 37 | at AAC | ||
| 10/6/2018 | Old Dominion | 33 | at | Florida Atlantic (5-7,3-5) | 52 | |||
| 10/13/2018 | Marshall (9-4,6-2) | 42 | at | Old Dominion | 20 | |||
| 10/20/2018 | Old Dominion | 37 | at | Western Kentucky (3-9,2-6) | 34 | |||
| 10/27/2018 | Middle Tenn State (8-6,7-2) | 51 | at | Old Dominion | 17 | |||
| 11/10/2018 | North Texas (9-4,5-3) | 31 | at | Old Dominion | 34 | |||
| 11/17/2018 | VMI (1-10) | 14 | at | Old Dominion | 77 | SoCon (1AA) | ||
| 11/24/2018 | Old Dominion | 13 | at | Rice (2-11,1-7) | 27 |
| vs Old Dominion | vs Other Opponents | Old Dominion compared to OOs | |
| Record: | 8-4 | 58-80 | |
| Points Scored: | 35.92 | 26.64 | -9.28 |
| Points Allowed: | 30.83 | 30.83 | 0 |
| Margin: | 5.09 | -4.19 | -9.28 |
| Total Points: | 66.75 | 57.47 | 9.28 |