| 8/30/2018 | Northwestern | 31 | at | Purdue (6-7,5-4) | 27 | |||
| 9/8/2018 | Duke (8-5) | 21 | at | Northwestern | 7 | ACC | ||
| 9/15/2018 | Akron (4-8) | 39 | at | Northwestern | 34 | MAC | ||
| 9/29/2018 | Michigan (10-3,8-1) | 20 | at | Northwestern | 17 | |||
| 10/6/2018 | Northwestern | 29 | at | Michigan State (7-6,5-4) | 19 | |||
| 10/13/2018 | Nebraska (4-8,3-6) | 31 | at | Northwestern | 34 | OT | ||
| 10/20/2018 | Northwestern | 18 | at | Rutgers (1-11,0-9) | 15 | |||
| 10/27/2018 | Wisconsin (8-5,5-4) | 17 | at | Northwestern | 31 | |||
| 11/3/2018 | Notre Dame (12-1) | 31 | at | Northwestern | 21 | ND | ||
| 11/10/2018 | Northwestern | 14 | at | Iowa (9-4,5-4) | 10 | |||
| 11/17/2018 | Northwestern | 24 | at | Minnesota (7-6,3-6) | 14 | |||
| 11/24/2018 | Illinois (4-8,2-7) | 16 | at | Northwestern | 24 | |||
| 12/1/2018 | Northwestern | 24 | vs | Ohio State (13-1,9-1) | 45 | Big 10 Championship Indianapolis IN | ||
| 12/31/2018 | Northwestern | 31 | vs | Utah (9-5) | 20 | SAN DIEGO COUNTY CREDIT UNION HOLIDAY BOWL - San Diego CA | vs P12 |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 5-9 | 97-69 | |
| Points Scored: | 23.21 | 28.77 | 5.56 |
| Points Allowed: | 24.21 | 25.11 | -0.90 |
| Margin: | -1.00 | 3.66 | 4.66 |
| Total Points: | 47.42 | 53.88 | -6.46 |