| 9/1/2018 | Appalachian State (11-2) | 38 | at | Penn State | 45 | OT | SBC | |
| 9/8/2018 | Penn State | 51 | at | Pittsburgh (7-7) | 6 | at ACC | ||
| 9/15/2018 | Kent State (2-10) | 10 | at | Penn State | 63 | MAC | ||
| 9/21/2018 | Penn State | 63 | at | Illinois (4-8,2-7) | 24 | |||
| 9/29/2018 | Ohio State (13-1,9-1) | 27 | at | Penn State | 26 | |||
| 10/13/2018 | Michigan State (7-6,5-4) | 21 | at | Penn State | 17 | |||
| 10/20/2018 | Penn State | 33 | at | Indiana (5-7,2-7) | 28 | |||
| 10/27/2018 | Iowa (9-4,5-4) | 24 | at | Penn State | 30 | |||
| 11/3/2018 | Penn State | 7 | at | Michigan (10-3,8-1) | 42 | |||
| 11/10/2018 | Wisconsin (8-5,5-4) | 10 | at | Penn State | 22 | |||
| 11/17/2018 | Penn State | 20 | at | Rutgers (1-11,0-9) | 7 | |||
| 11/24/2018 | Maryland (5-7,3-6) | 3 | at | Penn State | 38 | |||
| 1/1/2019 | Kentucky (10-3) | 37 | vs | Penn State | 24 | VRBO CITRUS BOWL - Orlando FL | SEC |
| vs Penn State | vs Other Opponents | Penn State compared to OOs | |
| Record: | 4-9 | 88-65 | |
| Points Scored: | 21.31 | 28.93 | 7.62 |
| Points Allowed: | 33.77 | 24.31 | 9.46 |
| Margin: | -12.46 | 4.62 | 17.08 |
| Total Points: | 55.08 | 53.24 | 1.84 |