| 9/1/2018 | Coastal Carolina (5-7) | 15 | at | South Carolina | 49 | SBC | ||
| 9/8/2018 | Georgia (11-3,7-2) | 41 | at | South Carolina | 17 | |||
| 9/15/2018 | Marshall (9-4) | vs | South Carolina | CCD | CUSA | |||
| 9/22/2018 | South Carolina | 37 | at | Vanderbilt (6-7,3-5) | 14 | |||
| 9/29/2018 | South Carolina | 10 | at | Kentucky (10-3,5-3) | 24 | |||
| 10/6/2018 | Missouri (8-5,4-4) | 35 | at | South Carolina | 37 | |||
| 10/13/2018 | Texas A&M (9-4,5-3) | 26 | at | South Carolina | 23 | |||
| 10/27/2018 | Tennessee (5-7,2-6) | 24 | at | South Carolina | 27 | |||
| 11/3/2018 | South Carolina | 48 | at | Mississippi (5-7,1-7) | 44 | |||
| 11/10/2018 | South Carolina | 31 | at | Florida (10-3,5-3) | 35 | |||
| 11/17/2018 | Chattanooga (6-5) | 9 | at | South Carolina | 49 | SoCon (1AA) | ||
| 11/24/2018 | South Carolina | 35 | at | Clemson (15-0) | 56 | at ACC | ||
| 12/1/2018 | Akron (4-8) | 3 | at | South Carolina | 28 | MAC | ||
| 12/29/2018 | South Carolina | 0 | vs | Virginia (8-5) | 28 | BELK BOWL - Charlotte NC | vs ACC |
| vs South Carolina | vs Other Opponents | South Carolina compared to OOs | |
| Record: | 6-7 | 105-61 | |
| Points Scored: | 27.23 | 31.11 | 3.88 |
| Points Allowed: | 30.08 | 23.07 | 7.01 |
| Margin: | -2.85 | 8.04 | 10.89 |
| Total Points: | 57.31 | 54.18 | 3.13 |