| 8/25/2018 | Prairie View (5-6) | 28 | at | Rice | 31 | SWAC (1AA) | ||
| 9/1/2018 | Houston (8-5) | 45 | at | Rice | 27 | AAC | ||
| 9/8/2018 | Rice | 29 | at | Hawaii (8-6) | 43 | at MW | ||
| 9/22/2018 | Rice | 22 | at | Southern Miss (6-5,5-3) | 40 | |||
| 9/29/2018 | Rice | 24 | at | Wake Forest (7-6) | 56 | at ACC | ||
| 10/6/2018 | Texas-San Antonio (3-9,2-6) | 20 | at | Rice | 3 | |||
| 10/13/2018 | UAB (11-3,8-1) | 42 | at | Rice | 0 | |||
| 10/20/2018 | Rice | 17 | at | Florida Intl (9-4,6-2) | 36 | |||
| 10/27/2018 | Rice | 17 | at | North Texas (9-4,5-3) | 41 | |||
| 11/3/2018 | UTEP (1-11,1-7) | 34 | at | Rice | 26 | |||
| 11/10/2018 | Rice | 13 | at | Louisiana Tech (8-5,5-3) | 28 | |||
| 11/17/2018 | Rice | 10 | at | LSU (10-3) | 42 | at SEC | ||
| 11/24/2018 | Old Dominion (4-8,2-6) | 13 | at | Rice | 27 |
| vs Rice | vs Other Opponents | Rice compared to OOs | |
| Record: | 11-2 | 78-73 | |
| Points Scored: | 36.00 | 29.33 | -6.67 |
| Points Allowed: | 18.92 | 28.72 | -9.80 |
| Margin: | 17.08 | 0.61 | -16.47 |
| Total Points: | 54.92 | 58.05 | -3.13 |