| 9/1/2018 | Elon (6-5) | 14 | at | South Florida | 34 | CAAF (1AA) | ||
| 9/8/2018 | Georgia Tech (7-6) | 38 | at | South Florida | 49 | ACC | ||
| 9/15/2018 | South Florida | 25 | vs | Illinois (4-8) | 19 | Chicago IL | vs B10 | |
| 9/22/2018 | East Carolina (3-9,1-7) | 13 | at | South Florida | 20 | |||
| 10/6/2018 | South Florida | 58 | at | Massachusetts (4-8) | 42 | at Ind | ||
| 10/12/2018 | South Florida | 25 | at | Tulsa (3-9,2-6) | 24 | |||
| 10/20/2018 | Connecticut (1-11,0-8) | 30 | at | South Florida | 38 | |||
| 10/27/2018 | South Florida | 36 | at | Houston (8-5,5-3) | 57 | |||
| 11/3/2018 | Tulane (7-6,5-3) | 41 | at | South Florida | 15 | |||
| 11/10/2018 | South Florida | 23 | at | Cincinnati (11-2,6-2) | 35 | |||
| 11/17/2018 | South Florida | 17 | at | Temple (8-5,7-1) | 27 | |||
| 11/23/2018 | UCF (12-1,9-0) | 38 | at | South Florida | 10 | |||
| 12/20/2018 | Marshall (9-4) | 38 | vs | South Florida | 20 | BAD BOY MOWERS GASPARILLA BOWL - Tampa FL | CUSA |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 6-7 | 77-72 | |
| Points Scored: | 32.00 | 30.74 | -1.26 |
| Points Allowed: | 28.46 | 31.30 | -2.84 |
| Margin: | 3.54 | -0.56 | -4.10 |
| Total Points: | 60.46 | 62.04 | -1.58 |