| 9/1/2018 | VMI (1-10) | 3 | at | Toledo | 66 | SoCon (1AA) | ||
| 9/15/2018 | Miami-Florida (7-6) | 49 | at | Toledo | 24 | ACC | ||
| 9/22/2018 | Nevada (8-5) | 44 | at | Toledo | 63 | MW | ||
| 9/29/2018 | Toledo | 27 | at | Fresno State (12-2) | 49 | at MW | ||
| 10/6/2018 | Bowling Green (3-9,2-6) | 36 | at | Toledo | 52 | |||
| 10/13/2018 | Toledo | 26 | at | Eastern Michigan (7-6,5-3) | 28 | |||
| 10/20/2018 | Buffalo (10-4,7-2) | 31 | at | Toledo | 17 | |||
| 10/25/2018 | Toledo | 51 | at | Western Michigan (7-6,5-3) | 24 | |||
| 10/31/2018 | Ball State (4-8,3-5) | 13 | at | Toledo | 45 | |||
| 11/7/2018 | Toledo | 15 | at | Northern Illinois (8-6,7-2) | 38 | |||
| 11/15/2018 | Toledo | 56 | at | Kent State (2-10,1-7) | 34 | |||
| 11/23/2018 | Central Michigan (1-11,0-8) | 13 | at | Toledo | 51 | |||
| 12/21/2018 | Florida Intl (9-4) | 35 | vs | Toledo | 32 | MAKERS WANTED BAHAMAS BOWL | CUSA |
| vs Toledo | vs Other Opponents | Toledo compared to OOs | |
| Record: | 6-7 | 73-80 | |
| Points Scored: | 30.54 | 27.16 | -3.38 |
| Points Allowed: | 40.38 | 27.37 | 13.01 |
| Margin: | -9.84 | -0.21 | 9.63 |
| Total Points: | 70.92 | 54.53 | 16.39 |