| 9/2/2018 | North Carolina A&T (10-2) | 28 | at | East Carolina | 23 | MEAC (1AA) | ||
| 9/8/2018 | North Carolina (2-9) | 19 | at | East Carolina | 41 | ACC | ||
| 9/15/2018 | East Carolina | vs | Virginia Tech (6-7) | CCD | vs ACC | |||
| 9/22/2018 | East Carolina | 13 | at | South Florida (7-6,3-5) | 20 | |||
| 9/29/2018 | Old Dominion (4-8) | 35 | at | East Carolina | 37 | CUSA | ||
| 10/6/2018 | East Carolina | 6 | at | Temple (8-5,7-1) | 49 | |||
| 10/13/2018 | Houston (8-5,5-3) | 42 | at | East Carolina | 20 | |||
| 10/20/2018 | UCF (12-1,9-0) | 37 | at | East Carolina | 10 | |||
| 11/3/2018 | Memphis (8-6,5-4) | 59 | at | East Carolina | 41 | |||
| 11/10/2018 | East Carolina | 18 | at | Tulane (7-6,5-3) | 24 | |||
| 11/17/2018 | Connecticut (1-11,0-8) | 21 | at | East Carolina | 55 | |||
| 11/23/2018 | East Carolina | 6 | at | Cincinnati (11-2,6-2) | 56 | |||
| 12/1/2018 | East Carolina | 3 | at | North Carolina State (9-4) | 58 | at ACC |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 9-3 | 84-69 | |
| Points Scored: | 37.33 | 32.93 | -4.40 |
| Points Allowed: | 22.75 | 30.16 | -7.41 |
| Margin: | 14.58 | 2.77 | -11.81 |
| Total Points: | 60.08 | 63.09 | -3.01 |