| 8/30/2018 | Quincy (4-7) | 0 | at | Indiana State | 49 | GLV (D2) | ||
| 9/8/2018 | Indiana State | 7 | at | Louisville (2-10) | 31 | at ACC | ||
| 9/15/2018 | Indiana State | 55 | at | Eastern Illinois (3-8) | 41 | at OVC | ||
| 9/27/2018 | Northern Iowa (7-6,5-3) | 33 | at | Indiana State | 0 | |||
| 10/6/2018 | Indiana State | 51 | at | South Dakota State (10-3,6-3) | 54 | OT | ||
| 10/13/2018 | Missouri State (4-7,2-6) | 29 | at | Indiana State | 26 | |||
| 10/20/2018 | Indiana State | 24 | at | Southern Illinois (2-9,1-7) | 21 | |||
| 10/27/2018 | Indiana State | 43 | at | Youngstown State (4-7,3-5) | 17 | |||
| 11/3/2018 | South Dakota (4-7,3-5) | 48 | at | Indiana State | 51 | |||
| 11/10/2018 | Illinois State (6-5,3-5) | 23 | at | Indiana State | 28 | |||
| 11/17/2018 | Indiana State | 15 | at | Western Illinois (5-6,4-4) | 13 |
| vs Indiana State | vs Other Opponents | Indiana State compared to OOs | |
| Record: | 4-7 | 47-68 | |
| Points Scored: | 28.18 | 26.82 | -1.36 |
| Points Allowed: | 31.73 | 30.89 | 0.84 |
| Margin: | -3.55 | -4.07 | -0.52 |
| Total Points: | 59.91 | 57.71 | 2.20 |