| 9/1/2018 | Northern Illinois | 7 | at | Iowa (9-4) | 33 | at B10 | ||
| 9/8/2018 | Utah (9-5) | 17 | at | Northern Illinois | 6 | P12 | ||
| 9/15/2018 | Central Michigan (1-11,0-8) | 16 | at | Northern Illinois | 24 | |||
| 9/22/2018 | Northern Illinois | 19 | at | Florida State (5-7) | 37 | at ACC | ||
| 9/29/2018 | Northern Illinois | 26 | at | Eastern Michigan (7-6,5-3) | 23 | 3OT | ||
| 10/6/2018 | Northern Illinois | 24 | at | Ball State (4-8,3-5) | 16 | |||
| 10/13/2018 | Ohio (9-4,6-2) | 21 | at | Northern Illinois | 24 | |||
| 10/27/2018 | Northern Illinois | 7 | at | BYU (7-6) | 6 | at Ind | ||
| 11/1/2018 | Northern Illinois | 36 | at | Akron (4-8,2-6) | 26 | |||
| 11/7/2018 | Toledo (7-6,5-3) | 15 | at | Northern Illinois | 38 | |||
| 11/14/2018 | Miami-Ohio (6-6,6-2) | 13 | at | Northern Illinois | 7 | |||
| 11/20/2018 | Northern Illinois | 21 | at | Western Michigan (7-6,5-3) | 28 | |||
| 11/30/2018 | Northern Illinois | 30 | vs | Buffalo (10-4,7-2) | 29 | MAC Championship Detroit MI | ||
| 12/18/2018 | UAB (11-3) | 37 | vs | Northern Illinois | 13 | CHERIBUNDI BOCA RATON BOWL - Boca Raton FL | CUSA |
| vs Northern Illinois | vs Other Opponents | Northern Illinois compared to OOs | |
| Record: | 6-8 | 90-76 | |
| Points Scored: | 22.64 | 29.20 | 6.56 |
| Points Allowed: | 20.14 | 25.78 | -5.64 |
| Margin: | 2.50 | 3.42 | 0.92 |
| Total Points: | 42.78 | 54.98 | -12.20 |