| 8/27/2016 | Charleston Southern | 17 | at | North Dakota State | 24 | @ MVC | ||
| 9/1/2016 | Presbyterian | 3 | at | Central Michigan | 49 | @ MAC (1A) | ||
| 9/3/2016 | Kentucky State | 7 | at | Charleston Southern | 57 | SIAC (D2) | ||
| Gardner-Webb | 31 | at | Elon | 6 | @ CAAF | |||
| East Tennessee St | 20 | at | Kennesaw St | 17 | 2OT | IndFCS | ||
| Monmouth NJ | 23 | at | Lehigh | 21 | @ Pat | |||
| Liberty | 13 | at | Virginia Tech | 36 | @ ACC (1A) | |||
| 9/10/2016 | Presbyterian | 0 | at | Chattanooga | 34 | @ SoCon | ||
| Monmouth NJ | 34 | at | Delaware State | 20 | @ MEAC | |||
| Charleston Southern | 8 | at | Florida State | 52 | @ ACC (1A) | |||
| Point | 3 | at | Kennesaw St | 49 | Sun (NAIA) | |||
| Jacksonville | 7 | at | Liberty | 55 | Pio | |||
| Gardner-Webb | 14 | at | Western Carolina | 44 | @ SoCon | |||
| 9/17/2016 | Presbyterian | 31 | at | Campbell | 14 | @ Pio | ||
| The Citadel | 31 | at | Gardner-Webb | 24 | SoCon | |||
| Monmouth NJ | 7 | at | Kent State | 27 | @ MAC (1A) | |||
| Liberty | 14 | at | SMU | 29 | @ AAC (1A) | |||
| 9/24/2016 | Kennesaw St | 36 | at | Duquesne | 28 | @ NE | ||
| Jacksonville State | 48 | at | Liberty | 19 | OVC | |||
| Charleston Southern | 35 | at | Monmouth NJ | 7 | ||||
| Gardner-Webb | 21 | at | Ohio | 37 | @ MAC (1A) | |||
| Florida Tech | 28 | at | Presbyterian | 7 | GSC (D2) | |||
| 10/1/2016 | Charleston Southern | 59 | at | Coastal Carolina | 58 | 2OT | @ IndFCS | |
| Kennesaw St | 52 | at | Furman | 42 | @ SoCon | |||
| Benedict | 0 | at | Gardner-Webb | 45 | SIAC (D2) | |||
| Robert Morris | 7 | at | Liberty | 41 | NE | |||
| Fordham | 41 | at | Monmouth NJ | 42 | OT | Pat | ||
| 10/8/2016 | Presbyterian | 3 | at | Gardner-Webb | 24 | |||
| Monmouth NJ | 59 | at | Howard | 27 | @ MEAC | |||
| Missouri S&T | 16 | at | Kennesaw St | 49 | GLV (D2) | |||
| 10/13/2016 | Monmouth NJ | 13 | at | Presbyterian | 17 | |||
| 10/15/2016 | Coastal Carolina | 17 | at | Gardner-Webb | 7 | IndFCS | ||
| Liberty | 36 | at | Kennesaw St | 21 | ||||
| 10/22/2016 | Presbyterian | 3 | at | Charleston Southern | 38 | |||
| Kennesaw St | 47 | at | Gardner-Webb | 39 | ||||
| Monmouth NJ | 28 | at | Liberty | 52 | ||||
| 10/29/2016 | Bucknell | 28 | at | Charleston Southern | 49 | Pat | ||
| Gardner-Webb | 20 | at | Liberty | 23 | OT | |||
| Kennesaw St | 49 | at | Monmouth NJ | 17 | ||||
| Coastal Carolina | 48 | at | Presbyterian | 17 | IndFCS | |||
| 11/5/2016 | Gardner-Webb | 17 | at | Charleston Southern | 10 | |||
| Monmouth NJ | 17 | at | Coastal Carolina | 38 | @ IndFCS | |||
| Clark Atlanta | 0 | at | Kennesaw St | 56 | SIAC (D2) | |||
| Liberty | 16 | at | Presbyterian | 0 | ||||
| 11/12/2016 | Presbyterian | 10 | at | Kennesaw St | 45 | |||
| Charleston Southern | 48 | at | Liberty | 26 | ||||
| 11/17/2016 | Liberty | 7 | at | Coastal Carolina | 42 | @ IndFCS | ||
| 11/19/2016 | Kennesaw St | 7 | at | Charleston Southern | 28 | |||
| Monmouth NJ | 33 | at | Gardner-Webb | 34 | OT | |||
| Presbyterian | 7 | at | South Alabama | 31 | @ SBC (1A) | |||
| 11/26/2016 | Charleston Southern | 14 | at | Wofford | 15 | @ SoCon |