| 9/3/2016 | South Alabama | 21 | at | Mississippi State (6-7) | 20 | at SEC | ||
| 9/10/2016 | Georgia Southern (5-7,4-4) | 24 | at | South Alabama | 9 | |||
| 9/17/2016 | South Alabama | 23 | at | UL Lafayette (6-7,5-3) | 28 | |||
| 9/24/2016 | Nicholls State (5-6) | 40 | at | South Alabama | 41 | OT | SLC (1AA) | |
| 10/1/2016 | San Diego State (11-3) | 24 | at | South Alabama | 42 | MW | ||
| 10/15/2016 | South Alabama | 7 | at | Arkansas State (8-5,7-1) | 17 | |||
| 10/20/2016 | Troy (10-3,6-2) | 28 | at | South Alabama | 21 | |||
| 10/29/2016 | Georgia State (3-9,2-6) | 10 | at | South Alabama | 13 | |||
| 11/5/2016 | South Alabama | 35 | at | UL Monroe (4-8,3-5) | 42 | OT | ||
| 11/19/2016 | Presbyterian (2-9) | 7 | at | South Alabama | 31 | BigS (1AA) | ||
| 11/26/2016 | South Alabama | 31 | at | Idaho (9-4,6-2) | 38 | |||
| 12/3/2016 | New Mexico State (3-9,2-6) | 28 | at | South Alabama | 35 | |||
| 12/30/2016 | South Alabama | 21 | vs | Air Force (10-3) | 45 | Arizona Bowl (Tuscon AZ) | vs MW |
| vs South Alabama | vs Other Opponents | South Alabama compared to OOs | |
| Record: | 7-6 | 75-74 | |
| Points Scored: | 27.00 | 27.26 | 0.26 |
| Points Allowed: | 25.38 | 28.52 | -3.14 |
| Margin: | 1.62 | -1.26 | -2.88 |
| Total Points: | 52.38 | 55.78 | -3.40 |