| 9/1/2016 | Wofford | 21 | at | Tennessee Tech (5-6) | 7 | at OVC | ||
| 9/10/2016 | Wofford | 13 | at | Mississippi (5-7) | 38 | at SEC | ||
| 9/17/2016 | Johnson C Smith (3-7) | 0 | at | Wofford | 59 | CIAA (D2) | ||
| 9/24/2016 | East Tennessee St (5-6) | 0 | at | Wofford | 31 | IndFCS | ||
| 10/1/2016 | Wofford | 26 | at | Samford (7-5,5-2) | 28 | |||
| 10/8/2016 | Wofford | 31 | at | Western Carolina (2-9,1-6) | 19 | |||
| 10/22/2016 | The Citadel (10-2,7-1) | 24 | at | Wofford | 21 | OT | ||
| 10/29/2016 | Mercer (6-5,3-4) | 21 | at | Wofford | 31 | |||
| 11/5/2016 | Wofford | 34 | at | Furman (3-8,2-5) | 27 | |||
| 11/12/2016 | Wofford | 36 | at | Chattanooga (9-4,5-2) | 28 | |||
| 11/19/2016 | VMI (3-8,0-7) | 0 | at | Wofford | 17 | |||
| 11/26/2016 | Charleston Southern (7-4) | 14 | at | Wofford | 15 | BigS | ||
| 12/3/2016 | Wofford | 17 | at | The Citadel (10-2,7-1) | 3 | 1AA Playoffs | ||
| 12/10/2016 | Wofford | 23 | at | Youngstown State (12-4) | 30 | 2OT | 1AA Quarterfinals | at MVC |
| vs Wofford | vs Other Opponents | Wofford compared to OOs | |
| Record: | 4-10 | 82-66 | |
| Points Scored: | 17.07 | 28.34 | 11.27 |
| Points Allowed: | 26.79 | 26.45 | 0.34 |
| Margin: | -9.72 | 1.89 | 11.61 |
| Total Points: | 43.86 | 54.79 | -10.93 |