| 9/1/2016 | North Alabama (11-2) | 12 | at | Jacksonville State | 31 | GSC (D2) | ||
| 9/10/2016 | Jacksonville State | 13 | at | LSU (8-4) | 34 | at SEC | ||
| 9/17/2016 | Coastal Carolina (10-2) | 26 | at | Jacksonville State | 27 | IndFCS | ||
| 9/24/2016 | Jacksonville State | 48 | at | Liberty (6-5) | 19 | at BigS | ||
| 10/8/2016 | Tennessee Tech (5-6,5-3) | 21 | at | Jacksonville State | 40 | |||
| 10/15/2016 | Austin Peay (0-11,0-8) | 14 | at | Jacksonville State | 34 | |||
| 10/22/2016 | Jacksonville State | 24 | at | Eastern Kentucky (3-8,2-6) | 7 | |||
| 10/29/2016 | Eastern Illinois (6-5,4-4) | 14 | at | Jacksonville State | 47 | |||
| 11/5/2016 | Jacksonville State | 17 | at | SE Missouri State (3-8,3-5) | 10 | |||
| 11/12/2016 | Jacksonville State | 33 | at | Murray State (4-7,4-4) | 15 | |||
| 11/19/2016 | Tennessee-Martin (7-5,6-2) | 7 | at | Jacksonville State | 33 | |||
| 12/3/2016 | Youngstown State (12-4) | 40 | at | Jacksonville State | 24 | 1AA Playoffs | MVC |
| vs Jacksonville State | vs Other Opponents | Jacksonville State compared to OOs | |
| Record: | 2-10 | 73-57 | |
| Points Scored: | 18.25 | 29.38 | 11.13 |
| Points Allowed: | 30.92 | 25.12 | 5.80 |
| Margin: | -12.67 | 4.26 | 16.93 |
| Total Points: | 49.17 | 54.50 | -5.33 |