| 9/3/2016 | Coastal Carolina | 38 | at | Lamar (3-8) | 14 | at SLC | ||
| 9/10/2016 | Florida A&M (4-7) | 10 | at | Coastal Carolina | 49 | MEAC | ||
| 9/17/2016 | Coastal Carolina | 26 | at | Jacksonville State (10-2) | 27 | at OVC | ||
| 9/24/2016 | Furman (3-8) | 21 | at | Coastal Carolina | 41 | SoCon | ||
| 10/1/2016 | Charleston Southern (7-4) | 59 | at | Coastal Carolina | 58 | 2OT | BigS | |
| 10/15/2016 | Coastal Carolina | 17 | at | Gardner-Webb (5-6) | 7 | at BigS | ||
| 10/22/2016 | Central Conn (2-9) | 25 | at | Coastal Carolina | 33 | NE | ||
| 10/29/2016 | Coastal Carolina | 48 | at | Presbyterian (2-9) | 17 | at BigS | ||
| 11/5/2016 | Monmouth NJ (4-7) | 17 | at | Coastal Carolina | 38 | BigS | ||
| 11/12/2016 | Bryant (5-6) | 21 | at | Coastal Carolina | 31 | NE | ||
| 11/17/2016 | Liberty (6-5) | 7 | at | Coastal Carolina | 42 | BigS | ||
| 11/26/2016 | Hampton (5-6) | 7 | at | Coastal Carolina | 26 | MEAC |
| vs Coastal Carolina | vs Other Opponents | Coastal Carolina compared to OOs | |
| Record: | 2-10 | 54-67 | |
| Points Scored: | 19.33 | 24.54 | 5.21 |
| Points Allowed: | 37.25 | 26.54 | 10.71 |
| Margin: | -17.92 | -2.00 | 15.92 |
| Total Points: | 56.58 | 51.08 | 5.50 |