| 9/3/2016 | East Tennessee St | 20 | at | Kennesaw St (8-3) | 17 | 2OT | at BigS | |
| 9/17/2016 | Western Carolina (2-9) | 31 | at | East Tennessee St | 34 | SoCon | ||
| 9/24/2016 | East Tennessee St | 0 | at | Wofford (10-4) | 31 | at SoCon | ||
| 10/1/2016 | Chattanooga (9-4) | 37 | at | East Tennessee St | 7 | SoCon | ||
| 10/8/2016 | East Tennessee St | 7 | at | VMI (3-8) | 37 | at SoCon | ||
| 10/15/2016 | Furman (3-8) | 52 | at | East Tennessee St | 7 | SoCon | ||
| 10/20/2016 | West Virginia Wesleyan (4-7) | 7 | at | East Tennessee St | 38 | MtnE (D2) | ||
| 10/29/2016 | East Tennessee St | 10 | at | The Citadel (10-2) | 45 | at SoCon | ||
| 11/5/2016 | East Tennessee St | 13 | at | Mercer (6-5) | 21 | at SoCon | ||
| 11/12/2016 | Cumberland TN (5-6) | 16 | at | East Tennessee St | 23 | MSC (NAIA) | ||
| 11/19/2016 | Samford (7-5) | 14 | at | East Tennessee St | 15 | SoCon |
| vs East Tennessee St | vs Other Opponents | East Tennessee St compared to OOs | |
| Record: | 6-5 | 61-56 | |
| Points Scored: | 28.00 | 28.35 | 0.35 |
| Points Allowed: | 15.82 | 25.90 | -10.08 |
| Margin: | 12.18 | 2.45 | -9.73 |
| Total Points: | 43.82 | 54.25 | -10.43 |