| 9/3/2016 | Bacone (2-8) | 14 | at | Missouri S&T | 62 | CSFL (NAIA) | ||
| 9/10/2016 | Missouri S&T | 28 | at | West Florida (5-6) | 45 | at GSC | ||
| 9/17/2016 | Truman State (8-3,7-1) | 44 | at | Missouri S&T | 20 | |||
| 9/24/2016 | Missouri S&T | 54 | at | St Joseph's (5-6,3-5) | 21 | |||
| 10/1/2016 | William Jewell (1-9,1-7) | 0 | at | Missouri S&T | 26 | |||
| 10/8/2016 | Missouri S&T | 16 | at | Kennesaw St (8-3) | 49 | at BigS | ||
| 10/15/2016 | Lincoln MO (1-10,0-8) | 16 | at | Missouri S&T | 65 | |||
| 10/22/2016 | Missouri S&T | 7 | at | McKendree (8-3,6-2) | 40 | |||
| 10/29/2016 | Missouri S&T | 22 | at | Southwest Baptist (10-2,7-1) | 45 | |||
| 11/5/2016 | Indianapolis (6-5,5-3) | 16 | at | Missouri S&T | 6 | |||
| 11/12/2016 | Missouri S&T | 24 | at | Quincy (5-6,3-5) | 20 |
| vs Missouri S&T | vs Other Opponents | Missouri S&T compared to OOs | |
| Record: | 6-5 | 53-56 | |
| Points Scored: | 28.18 | 27.45 | -0.73 |
| Points Allowed: | 30.00 | 28.61 | 1.39 |
| Margin: | -1.82 | -1.16 | 0.66 |
| Total Points: | 58.18 | 56.06 | 2.12 |