| 9/3/2016 | Liberty (6-5) | 13 | at | Virginia Tech | 36 | BigS (1AA) | ||
| 9/10/2016 | Virginia Tech | 24 | vs | Tennessee (9-4) | 45 | Bristol TN | vs SEC | |
| 9/17/2016 | Boston College (7-6,2-6) | 0 | at | Virginia Tech | 49 | |||
| 9/24/2016 | East Carolina (3-9) | 17 | at | Virginia Tech | 54 | AAC | ||
| 10/8/2016 | Virginia Tech | 34 | at | North Carolina (8-5,5-3) | 3 | |||
| 10/15/2016 | Virginia Tech | 17 | at | Syracuse (4-8,2-6) | 31 | |||
| 10/20/2016 | Miami-Florida (9-4,5-3) | 16 | at | Virginia Tech | 37 | |||
| 10/27/2016 | Virginia Tech | 39 | at | Pittsburgh (8-5,5-3) | 36 | |||
| 11/5/2016 | Virginia Tech | 24 | at | Duke (4-8,1-7) | 21 | |||
| 11/12/2016 | Georgia Tech (9-4,4-4) | 30 | at | Virginia Tech | 20 | |||
| 11/19/2016 | Virginia Tech | 34 | at | Notre Dame (4-8) | 31 | at ND | ||
| 11/26/2016 | Virginia (2-10,1-7) | 10 | at | Virginia Tech | 52 | |||
| 12/3/2016 | Clemson (14-1,8-1) | 42 | vs | Virginia Tech | 35 | Orlando FL | ||
| 12/29/2016 | Arkansas (7-6) | 24 | vs | Virginia Tech | 35 | Belk Bowl (Charlotte NC) | SEC |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 4-10 | 90-73 | |
| Points Scored: | 22.79 | 30.80 | 8.01 |
| Points Allowed: | 35.00 | 27.51 | 7.49 |
| Margin: | -12.21 | 3.29 | 15.50 |
| Total Points: | 57.79 | 58.31 | -0.52 |