| 9/4/2010 | Western Michigan Broncos 14 @ Michigan State 38 | |
| 9/11/2010 | Michigan State 30 vs Florida Atlantic Owls 17 (Detroit MI) | |
| 9/18/2010 | Notre Dame Fighting Irish 31 @ Michigan State 34 1OT | |
| 9/25/2010 | Northern Colorado Bears 7 @ Michigan State 45 | |
| 10/2/2010 | Wisconsin Badgers 24 @ Michigan State 34 | † |
| 10/9/2010 | Michigan State 34 @ Michigan Wolverines 17 | † |
| 10/16/2010 | Illinois Fighting Illini 6 @ Michigan State 26 | † |
| 10/23/2010 | Michigan State 35 @ Northwestern Wildcats 27 | † |
| 10/30/2010 | Michigan State 6 @ Iowa Hawkeyes 37 | † |
| 11/6/2010 | Minnesota Golden Gophers 8 @ Michigan State 31 | † |
| 11/20/2010 | Purdue Boilermakers 31 @ Michigan State 35 | † |
| 11/27/2010 | Michigan State 28 @ Penn State Nittany Lions 22 | † |
| 1/1/2011 | Alabama Crimson Tide 49 vs Michigan State 7 (Orlando - Capital One Bowl) |