| 9/2/2010 | Minnesota 24 @ Middle Tenn State Blue Raiders 17 | |
| 9/11/2010 | South Dakota Coyotes 41 @ Minnesota 38 | |
| 9/18/2010 | Southern California Trojans 32 @ Minnesota 21 | |
| 9/25/2010 | Northern Illinois Huskies 34 @ Minnesota 23 | |
| 10/2/2010 | Northwestern Wildcats 29 @ Minnesota 28 | † |
| 10/9/2010 | Minnesota 23 @ Wisconsin Badgers 41 | † |
| 10/16/2010 | Minnesota 17 @ Purdue Boilermakers 28 | † |
| 10/23/2010 | Penn State Nittany Lions 33 @ Minnesota 21 | † |
| 10/30/2010 | Ohio State Buckeyes 52 @ Minnesota 10 | † |
| 11/6/2010 | Minnesota 8 @ Michigan State Spartans 31 | † |
| 11/13/2010 | Minnesota 38 @ Illinois Fighting Illini 34 | † |
| 11/27/2010 | Iowa Hawkeyes 24 @ Minnesota 27 | † |