| 9/5/2010 | SMU Mustangs 27 @ Texas Tech 35 | |
| 9/11/2010 | Texas Tech 52 @ New Mexico Lobos 17 | |
| 9/18/2010 | Texas Longhorns 24 @ Texas Tech 14 | † |
| 10/2/2010 | Texas Tech 38 @ Iowa State Cyclones 52 | † |
| 10/9/2010 | Texas Tech 45 vs Baylor Bears 38 (Dallas TX) | † |
| 10/16/2010 | Oklahoma State Cowboys 34 @ Texas Tech 17 | † |
| 10/23/2010 | Texas Tech 27 @ Colorado Buffaloes 24 | † |
| 10/30/2010 | Texas Tech 27 @ Texas A&M Aggies 45 | † |
| 11/6/2010 | Missouri Tigers 17 @ Texas Tech 24 | † |
| 11/13/2010 | Texas Tech 7 @ Oklahoma Sooners 45 | † |
| 11/20/2010 | Weber State Wildcats 21 @ Texas Tech 58 | |
| 11/27/2010 | Houston Cougars 20 @ Texas Tech 35 | |
| 1/1/2011 | Northwestern Wildcats 38 vs Texas Tech 45 (Dallas - TicketCity Bowl) |