| 9/2/2010 | Towson Tigers 17 @ Indiana 51 | |
| 9/18/2010 | Indiana 38 @ Western Kentucky Hilltoppers 21 | |
| 9/25/2010 | Akron Zips 20 @ Indiana 35 | |
| 10/2/2010 | Michigan Wolverines 42 @ Indiana 35 | † |
| 10/9/2010 | Indiana 10 @ Ohio State Buckeyes 38 | † |
| 10/16/2010 | Arkansas State Red Wolves 34 @ Indiana 36 | |
| 10/23/2010 | Indiana 13 @ Illinois Fighting Illini 43 | † |
| 10/30/2010 | Northwestern Wildcats 20 @ Indiana 17 | † |
| 11/6/2010 | Iowa Hawkeyes 18 @ Indiana 13 | † |
| 11/13/2010 | Indiana 20 @ Wisconsin Badgers 83 | † |
| 11/20/2010 | Penn State Nittany Lions 41 vs Indiana 24 (Landover MD) | † |
| 11/27/2010 | Indiana 34 @ Purdue Boilermakers 31 1OT | † |