| 9/4/2010 | Western Carolina Catamounts 7 @ North Carolina State 48 | |
| 9/11/2010 | North Carolina State 28 @ UCF Knights 21 | |
| 9/16/2010 | Cincinnati Bearcats 19 @ North Carolina State 30 | |
| 9/25/2010 | North Carolina State 45 @ Georgia Tech Yellow Jackets 28 | † |
| 10/2/2010 | Virginia Tech Hokies 41 @ North Carolina State 30 | † |
| 10/9/2010 | Boston College Eagles 17 @ North Carolina State 44 | † |
| 10/16/2010 | North Carolina State 27 @ East Carolina Pirates 33 1OT | |
| 10/28/2010 | Florida State Seminoles 24 @ North Carolina State 28 | † |
| 11/6/2010 | North Carolina State 13 @ Clemson Tigers 14 | † |
| 11/13/2010 | Wake Forest Demon Deacons 3 @ North Carolina State 38 | † |
| 11/20/2010 | North Carolina State 29 @ North Carolina Tar Heels 25 | † |
| 11/27/2010 | North Carolina State 31 @ Maryland Terrapins 38 | † |
| 12/28/2010 | West Virginia Mountaineers 7 vs North Carolina State 23 (Orlando - Champs Sports Bowl) |