| 9/4/2010 | LSU Tigers 30 vs North Carolina 24 (Atlanta GA) | |
| 9/18/2010 | Georgia Tech Yellow Jackets 30 @ North Carolina 24 | † |
| 9/25/2010 | North Carolina 17 @ Rutgers Scarlet Knights 13 | |
| 10/2/2010 | East Carolina Pirates 17 @ North Carolina 42 | |
| 10/9/2010 | Clemson Tigers 16 @ North Carolina 21 | † |
| 10/16/2010 | North Carolina 44 @ Virginia Cavaliers 10 | † |
| 10/23/2010 | North Carolina 10 @ Miami-Florida Hurricanes 33 | † |
| 10/30/2010 | William & Mary Tribe 17 @ North Carolina 21 | |
| 11/6/2010 | North Carolina 37 @ Florida State Seminoles 35 | † |
| 11/13/2010 | Virginia Tech Hokies 26 @ North Carolina 10 | † |
| 11/20/2010 | North Carolina State Wolfpack 29 @ North Carolina 25 | † |
| 11/27/2010 | North Carolina 24 @ Duke Blue Devils 19 | † |
| 12/30/2010 | North Carolina 30 vs Tennessee Volunteers 27 (Nashville - Music City Bowl) |