| 9/4/2010 | North Texas Eagles 10 @ Clemson 35 | |
| 9/11/2010 | Presbyterian Blue Hose 21 @ Clemson 58 | |
| 9/18/2010 | Clemson 24 @ Auburn Tigers 27 1OT | |
| 10/2/2010 | Miami-Florida Hurricanes 30 @ Clemson 21 | † |
| 10/9/2010 | Clemson 16 @ North Carolina Tar Heels 21 | † |
| 10/16/2010 | Maryland Terrapins 7 @ Clemson 31 | † |
| 10/23/2010 | Georgia Tech Yellow Jackets 13 @ Clemson 27 | † |
| 10/30/2010 | Clemson 10 @ Boston College Eagles 16 | † |
| 11/6/2010 | North Carolina State Wolfpack 13 @ Clemson 14 | † |
| 11/13/2010 | Clemson 13 @ Florida State Seminoles 16 | † |
| 11/20/2010 | Clemson 30 @ Wake Forest Demon Deacons 10 | † |
| 11/27/2010 | South Carolina Gamecocks 29 @ Clemson 7 | |
| 12/31/2010 | South Florida Bulls 31 vs Clemson 26 (Charlotte - Meineke Bowl) |