| 9/6/2010 | Boise State Broncos 33 vs Virginia Tech 30 (Landover MD) | |
| 9/11/2010 | James Madison Dukes 21 @ Virginia Tech 16 | |
| 9/18/2010 | East Carolina Pirates 27 @ Virginia Tech 49 | |
| 9/25/2010 | Virginia Tech 19 @ Boston College Eagles 0 | † |
| 10/2/2010 | Virginia Tech 41 @ North Carolina State Wolfpack 30 | † |
| 10/9/2010 | Central Michigan Chippewas 21 @ Virginia Tech 45 | |
| 10/16/2010 | Wake Forest Demon Deacons 21 @ Virginia Tech 52 | † |
| 10/23/2010 | Duke Blue Devils 7 @ Virginia Tech 44 | † |
| 11/4/2010 | Georgia Tech Yellow Jackets 21 @ Virginia Tech 28 | † |
| 11/13/2010 | Virginia Tech 26 @ North Carolina Tar Heels 10 | † |
| 11/20/2010 | Virginia Tech 31 @ Miami-Florida Hurricanes 17 | † |
| 11/27/2010 | Virginia Cavaliers 7 @ Virginia Tech 37 | † |
| 12/4/2010 | Florida State Seminoles 33 vs Virginia Tech 44 (Charlotte NC-ACC Championship) | † |
| 1/3/2011 | Stanford Cardinal 40 vs Virginia Tech 12 (Miami - Orange Bowl) |