| 9/4/2010 | Richmond Spiders 13 @ Virginia 34 | |
| 9/11/2010 | Virginia 7 @ Southern California Trojans 17 | |
| 9/25/2010 | VMI Keydets 7 @ Virginia 48 | |
| 10/2/2010 | Florida State Seminoles 34 @ Virginia 14 | † |
| 10/9/2010 | Virginia 21 @ Georgia Tech Yellow Jackets 33 | † |
| 10/16/2010 | North Carolina Tar Heels 44 @ Virginia 10 | † |
| 10/23/2010 | Eastern Michigan Eagles 21 @ Virginia 48 | |
| 10/30/2010 | Miami-Florida Hurricanes 19 @ Virginia 24 | † |
| 11/6/2010 | Virginia 48 @ Duke Blue Devils 56 | † |
| 11/13/2010 | Maryland Terrapins 42 @ Virginia 23 | † |
| 11/20/2010 | Virginia 13 @ Boston College Eagles 17 | † |
| 11/27/2010 | Virginia 7 @ Virginia Tech Hokies 37 | † |