| 8/27/2022 | Arkansas Baptist | 7 | at | Bethel TN | 77 | @ MSC (NAIA) | ||
| North American U | 13 | at | Southeastern FL | 54 | @ Sun (NAIA) | |||
| Lincoln CA | 10 | at | Webber International | 35 | @ Sun (NAIA) | |||
| 9/1/2022 | Lincoln CA | 7 | at | Texas A&M-Commerce | 52 | @ SLC (1AA) | ||
| Virginia U-Lynchburg | 0 | at | Virginia Union | 77 | @ CIAA (D2) | |||
| 9/3/2022 | Texas College | 12 | at | Arkansas Baptist | 31 | Soon (NAIA) | ||
| Apprentice | 27 | at | Averett | 14 | @ ODC (D3) | |||
| Fort Lauderdale | 2 | at | Erskine | 49 | @ SAC (D2) | |||
| North American U | 0 | at | Texas A&M-Kingsville | 60 | @ LSC (D2) | |||
| 9/10/2022 | Brevard | 7 | at | Apprentice | 27 | USASC (D3) | ||
| North American U | 3 | at | Ark Pine Bluff | 76 | @ SWAC (1AA) | |||
| Ave Maria | at | Fort Lauderdale | CCD | Sun (NAIA) | ||||
| Virginia U-Lynchburg | 13 | at | Presbyterian | 21 | @ Pio (1AA) | |||
| Lincoln CA | 10 | at | Western Oregon | 42 | @ LSC (D2) | |||
| 9/17/2022 | Apprentice | 38 | at | Christopher Newport | 35 | @ NJAC (D3) | ||
| Virginia U-Lynchburg | 19 | at | Delaware State | 35 | @ MEAC (1AA) | |||
| Lincoln CA | 7 | at | Grand Valley State | 66 | @ GLIAC (D2) | |||
| Fort Lauderdale | 0 | at | Southeastern FL | 1 | Forfeit | @ Sun (NAIA) | ||
| North American U | 0 | at | St Thomas FL | 52 | @ Sun (NAIA) | |||
| 9/24/2022 | Langston | 45 | at | Arkansas Baptist | 8 | Soon (NAIA) | ||
| Virginia U-Lynchburg | 14 | at | North Carolina Central | 59 | @ MEAC (1AA) | |||
| Lincoln CA | 6 | at | St Thomas | 43 | @ Pio (1AA) | |||
| North American U | 3 | at | Texas A&M-Commerce | 63 | @ SLC (1AA) | |||
| Fort Lauderdale | at | Webber International | 1 | Forfeit | @ Sun (NAIA) | |||
| 10/1/2022 | Apprentice | 19 | at | Bluefield St WV | 22 | @ D2Ind (D2) | ||
| Virginia U-Lynchburg | 10 | at | Morgan State | 44 | @ MEAC (1AA) | |||
| Texas Lutheran | 45 | at | North American U | 17 | ASWC (D3) | |||
| Fort Lauderdale | at | St Thomas FL | 1 | Forfeit | @ Sun (NAIA) | |||
| Arkansas Baptist | 20 | at | Southwestern Assemblies of God | 47 | @ Soon (NAIA) | |||
| 10/8/2022 | Bluefield St WV | at | Fort Lauderdale | CCD | D2Ind (D2) | |||
| Arkansas Baptist | 14 | at | Louisiana College | 42 | @ Soon (NAIA) | |||
| Lincoln CA | 6 | at | Portland State | 48 | @ BSky (1AA) | |||
| Virginia U-Lynchburg | 14 | at | Savannah State | 28 | @ SIAC (D2) | |||
| 10/14/2022 | Lincoln CA | 70 | at | Hilbert | 0 | @ D3Ind (D3) | ||
| 10/15/2022 | Virginia U-Lynchburg | 0 | at | South Carolina State | 36 | @ MEAC (1AA) | ||
| 10/22/2022 | Lincoln CA | 14 | at | Davenport | 58 | @ GLIAC (D2) | ||
| Arkansas Baptist | 14 | at | North American U | 47 | ||||
| Virginia U-Lynchburg | 7 | at | Southern | 51 | @ SWAC (1AA) | |||
| 10/29/2022 | Avila | 36 | at | Arkansas Baptist | 6 | KCAC (NAIA) | ||
| Lincoln CA | 2 | at | Texas Southern | 37 | @ SWAC (1AA) | |||
| Virginia U-Lynchburg | 20 | at | Webber International | 38 | @ Sun (NAIA) | |||
| 11/5/2022 | Lincoln CA | 20 | at | Bluefield St WV | 17 | @ D2Ind (D2) | ||
| Arkansas Baptist | 10 | at | Kansas Wesleyan | 67 | @ KCAC (NAIA) | |||
| North American U | 7 | at | Texas Wesleyan | 61 | @ Soon (NAIA) | |||
| 11/12/2022 | North American U | 6 | at | East Texas Baptist | 43 | @ ASWC (D3) | ||
| Lincoln CA | 0 | at | Southern Utah | 55 | @ WAC (1AA) | |||
| Virginia U-Lynchburg | 0 | at | The Citadel | 66 | @ SoCon (1AA) |