| 9/3/2022 | Texas Wesleyan | 48 | at | Arizona Christian (8-3,7-2) | 21 | |||
| 9/10/2022 | Panhandle State (4-6,4-5) | 0 | at | Texas Wesleyan | 52 | |||
| 9/17/2022 | Ottawa AZ (7-2,7-2) | 27 | at | Texas Wesleyan | 22 | |||
| 10/1/2022 | Texas Wesleyan | 59 | at | Wayland Baptist (2-8,2-7) | 16 | |||
| 10/8/2022 | Southwestern Assemblies of God (7-4,6-3) | 0 | at | Texas Wesleyan | 35 | |||
| 10/15/2022 | Langston (6-4,5-4) | 28 | at | Texas Wesleyan | 53 | |||
| 10/22/2022 | Texas Wesleyan | 9 | at | Louisiana College (7-4,6-3) | 33 | |||
| 10/29/2022 | Texas Wesleyan | 40 | at | Texas College (1-9,1-8) | 12 | |||
| 11/5/2022 | North American U (1-8) | 7 | at | Texas Wesleyan | 61 | None (Unk?) | ||
| 11/12/2022 | Lyon (1-9,0-9) | 21 | at | Texas Wesleyan | 64 |
| vs Texas Wesleyan | vs Other Opponents | Texas Wesleyan compared to OOs | |
| Record: | 2-8 | 42-49 | |
| Points Scored: | 16.50 | 27.54 | 11.04 |
| Points Allowed: | 44.30 | 31.14 | 13.16 |
| Margin: | -27.80 | -3.60 | 24.20 |
| Total Points: | 60.80 | 58.68 | 2.12 |