| 9/3/2022 | Panhandle State (4-6,4-5) | 13 | at | Langston | 48 | |||
| 9/10/2022 | Langston | 55 | at | Texas College (1-9,1-8) | 24 | |||
| 9/17/2022 | Wayland Baptist (2-8,2-7) | 24 | at | Langston | 56 | |||
| 9/24/2022 | Langston | 45 | at | Arkansas Baptist (1-7) | 8 | at None | ||
| 10/1/2022 | Lyon (1-9,0-9) | 3 | at | Langston | 43 | |||
| 10/15/2022 | Langston | 28 | at | Texas Wesleyan (8-2,7-2) | 53 | |||
| 10/22/2022 | Ottawa AZ (7-2,7-2) | 38 | at | Langston | 44 | OT | ||
| 10/29/2022 | Louisiana College (7-4,6-3) | 39 | at | Langston | 14 | |||
| 11/5/2022 | Langston | 27 | at | Arizona Christian (8-3,7-2) | 30 | |||
| 11/12/2022 | Langston | 21 | at | Southwestern Assemblies of God (7-4,6-3) | 39 |
| vs Langston | vs Other Opponents | Langston compared to OOs | |
| Record: | 4-6 | 42-48 | |
| Points Scored: | 27.10 | 27.51 | 0.41 |
| Points Allowed: | 38.10 | 29.94 | 8.16 |
| Margin: | -11.00 | -2.43 | 8.57 |
| Total Points: | 65.20 | 57.45 | 7.75 |