| 9/3/2022 | Florida Memorial (2-7) | 0 | at | Southern | 86 | Sun (NAIA) | ||
| 9/10/2022 | Southern | 17 | at | LSU (10-4) | 65 | at SEC | ||
| 9/17/2022 | Southern | 0 | vs | Texas Southern (5-6,4-4) | 24 | Arlington TX | ||
| 10/1/2022 | Ark Pine Bluff (3-8,1-7) | 3 | at | Southern | 59 | |||
| 10/8/2022 | Southern | 45 | at | Prairie View (6-5,5-3) | 13 | |||
| 10/15/2022 | Alcorn State (5-6,4-4) | 17 | at | Southern | 21 | |||
| 10/22/2022 | Virginia U-Lynchburg (0-10) | 7 | at | Southern | 51 | None (Unk?) | ||
| 10/29/2022 | Southern | 0 | at | Jackson State (12-1,10-0) | 35 | |||
| 11/5/2022 | Southern | 16 | at | Florida A&M (9-2,7-1) | 30 | |||
| 11/12/2022 | Mississippi Valley State (2-9,2-6) | 7 | at | Southern | 27 | |||
| 11/26/2022 | Grambling (3-8,2-7) | 17 | vs | Southern | 34 | New Orleans LA | ||
| 12/3/2022 | Southern | 24 | at | Jackson State (12-1,10-0) | 43 | SWAC Championship |
| vs Southern | vs Other Opponents | Southern compared to OOs | |
| Record: | 5-7 | 62-60 | |
| Points Scored: | 21.75 | 26.70 | 4.95 |
| Points Allowed: | 31.67 | 27.07 | 4.60 |
| Margin: | -9.92 | -0.37 | 9.55 |
| Total Points: | 53.42 | 53.77 | -0.35 |