| 8/31/2017 | Ohio State | 49 | at | Indiana | 21 | |||
| Buffalo | 7 | at | Minnesota | 17 | MAC | |||
| 9/1/2017 | Washington | 30 | at | Rutgers | 14 | P12 | ||
| Utah State | 10 | at | Wisconsin | 59 | MW | |||
| 9/2/2017 | Michigan | 33 | vs | Florida | 17 | Arlington TX | vs SEC | |
| Ball State | 21 | at | Illinois | 24 | MAC | |||
| Wyoming | 3 | at | Iowa | 24 | MW | |||
| Bowling Green | 10 | at | Michigan State | 35 | MAC | |||
| Arkansas State | 36 | at | Nebraska | 43 | SBC | |||
| Nevada | 20 | at | Northwestern | 31 | MW | |||
| Akron | 0 | at | Penn State | 52 | MAC | |||
| Louisville | 35 | vs | Purdue | 28 | Indianapolis IN | vs ACC | ||
| Maryland | 51 | at | Texas | 41 | @ B12 | |||
| 9/8/2017 | Ohio | 21 | at | Purdue | 44 | MAC | ||
| 9/9/2017 | Northwestern | 17 | at | Duke | 41 | @ ACC | ||
| Western Kentucky | 7 | at | Illinois | 20 | CUSA | |||
| Iowa | 44 | at | Iowa State | 41 | OT | @ B12 | ||
| Towson | 17 | at | Maryland | 63 | CAAF (1AA) | |||
| Cincinnati | 14 | at | Michigan | 36 | AAC | |||
| Western Michigan | 14 | at | Michigan State | 28 | MAC | |||
| Oklahoma | 31 | at | Ohio State | 16 | B12 | |||
| Nebraska | 35 | at | Oregon | 42 | @ P12 | |||
| Minnesota | 48 | at | Oregon State | 14 | @ P12 | |||
| Pittsburgh | 14 | at | Penn State | 33 | ACC | |||
| Eastern Michigan | 16 | at | Rutgers | 13 | MAC | |||
| Indiana | 34 | at | Virginia | 17 | @ ACC | |||
| Florida Atlantic | 14 | at | Wisconsin | 31 | CUSA | |||
| 9/15/2017 | Illinois | 23 | at | South Florida | 47 | @ AAC | ||
| 9/16/2017 | Wisconsin | 40 | at | BYU | 6 | @ Ind | ||
| Florida Intl | vs | Indiana | Cancelled WX | vs CUSA | ||||
| North Texas | 14 | at | Iowa | 31 | CUSA | |||
| Air Force | 13 | at | Michigan | 29 | MW | |||
| Middle Tenn State | 3 | at | Minnesota | 34 | CUSA | |||
| Purdue | 35 | at | Missouri | 3 | @ SEC | |||
| Northern Illinois | 21 | at | Nebraska | 17 | MAC | |||
| Bowling Green | 7 | at | Northwestern | 49 | MAC | |||
| Army | 7 | at | Ohio State | 38 | Ind | |||
| Georgia State | 0 | at | Penn State | 56 | SBC | |||
| Morgan State | 0 | at | Rutgers | 65 | MEAC (1AA) | |||
| 9/23/2017 | Georgia Southern | 17 | at | Indiana | 52 | SBC | ||
| Penn State | 21 | at | Iowa | 19 | ||||
| UCF | 38 | at | Maryland | 10 | AAC | |||
| Notre Dame | 38 | at | Michigan State | 18 | ND | |||
| Rutgers | 17 | at | Nebraska | 27 | ||||
| UNLV | 21 | at | Ohio State | 54 | MW | |||
| Michigan | 28 | at | Purdue | 10 | ||||
| 9/29/2017 | Nebraska | 28 | at | Illinois | 6 | |||
| 9/30/2017 | Iowa | 10 | at | Michigan State | 17 | |||
| Maryland | 31 | at | Minnesota | 24 | ||||
| Indiana | 14 | at | Penn State | 45 | ||||
| Ohio State | 56 | at | Rutgers | 0 | ||||
| Northwestern | 24 | at | Wisconsin | 33 | ||||
| 10/7/2017 | Charleston Southern | 0 | at | Indiana | 27 | BigS (1AA) | ||
| Illinois | 16 | at | Iowa | 45 | ||||
| Michigan State | 14 | at | Michigan | 10 | ||||
| Wisconsin | 38 | at | Nebraska | 17 | ||||
| Penn State | 31 | at | Northwestern | 7 | ||||
| Maryland | 14 | at | Ohio State | 62 | ||||
| Minnesota | 17 | at | Purdue | 31 | ||||
| 10/14/2017 | Rutgers | 35 | at | Illinois | 24 | |||
| Michigan | 27 | at | Indiana | 20 | OT | |||
| Northwestern | 37 | at | Maryland | 21 | ||||
| Michigan State | 30 | at | Minnesota | 27 | ||||
| Ohio State | 56 | at | Nebraska | 14 | ||||
| Purdue | 9 | at | Wisconsin | 17 | ||||
| 10/21/2017 | Indiana | 9 | at | Michigan State | 17 | |||
| Illinois | 17 | at | Minnesota | 24 | ||||
| Iowa | 10 | at | Northwestern | 17 | ||||
| Michigan | 13 | at | Penn State | 42 | ||||
| Purdue | 12 | at | Rutgers | 14 | ||||
| Maryland | 13 | at | Wisconsin | 38 | ||||
| 10/28/2017 | Wisconsin | 24 | at | Illinois | 10 | |||
| Minnesota | 10 | at | Iowa | 17 | ||||
| Indiana | 39 | at | Maryland | 42 | ||||
| Rutgers | 14 | at | Michigan | 35 | ||||
| Michigan State | 31 | at | Northwestern | 39 | 3OT | |||
| Penn State | 38 | at | Ohio State | 39 | ||||
| Nebraska | 25 | at | Purdue | 24 | ||||
| 11/4/2017 | Wisconsin | 45 | at | Indiana | 17 | |||
| Ohio State | 24 | at | Iowa | 55 | ||||
| Minnesota | 10 | at | Michigan | 33 | ||||
| Penn State | 24 | at | Michigan State | 27 | ||||
| Northwestern | 31 | at | Nebraska | 24 | OT | |||
| Illinois | 10 | at | Purdue | 29 | ||||
| Maryland | 24 | at | Rutgers | 31 | ||||
| 11/11/2017 | Indiana | 24 | at | Illinois | 14 | |||
| Michigan | 35 | at | Maryland | 10 | ||||
| Nebraska | 21 | at | Minnesota | 54 | ||||
| Purdue | 13 | at | Northwestern | 23 | ||||
| Michigan State | 3 | at | Ohio State | 48 | ||||
| Rutgers | 6 | at | Penn State | 35 | ||||
| Iowa | 14 | at | Wisconsin | 38 | ||||
| 11/18/2017 | Rutgers | 0 | at | Indiana | 41 | |||
| Purdue | 24 | at | Iowa | 15 | ||||
| Maryland | 7 | at | Michigan State | 17 | ||||
| Minnesota | 0 | at | Northwestern | 39 | ||||
| Illinois | 14 | at | Ohio State | 52 | ||||
| Nebraska | 44 | at | Penn State | 56 | ||||
| Michigan | 10 | at | Wisconsin | 24 | ||||
| 11/24/2017 | Iowa | 56 | at | Nebraska | 14 | |||
| 11/25/2017 | Northwestern | 42 | at | Illinois | 7 | |||
| Penn State | 66 | at | Maryland | 3 | ||||
| Ohio State | 31 | at | Michigan | 20 | ||||
| Wisconsin | 31 | at | Minnesota | 0 | ||||
| Indiana | 24 | at | Purdue | 31 | ||||
| Michigan State | 40 | at | Rutgers | 7 | ||||
| 12/2/2017 | Ohio State | 27 | vs | Wisconsin | 21 | Big10 Championship (Indianapolis IN) | ||
| 12/27/2017 | Iowa | 27 | vs | Boston College | 20 | Pinstripe Bowl (New York NY) | vs ACC | |
| Arizona | 35 | vs | Purdue | 38 | Foster Farms Bowl (Santa Clasra CA) | vs P12 | ||
| 12/28/2017 | Washington State | 17 | vs | Michigan State | 42 | Holiday Bowl (San Diego) | vs P12 | |
| 12/29/2017 | Kentucky | 23 | vs | Northwestern | 24 | Music City Bowl (Nashville TN) | vs SEC | |
| Southern California | 7 | vs | Ohio State | 24 | Cotton Bowl (Arlington TX) | vs P12 | ||
| 12/30/2017 | Wisconsin | 34 | vs | Miami-Florida | 24 | Orange Bowl (Miami FL) | vs ACC | |
| Washington | 28 | vs | Penn State | 35 | Fiesta Bowl (Glendale AZ) | vs P12 | ||
| 1/1/2018 | Michigan | 19 | vs | South Carolina | 26 | Outback Bowl (Tampa FL) | vs SEC |