| 9/2/2017 | Vanderbilt (5-7) | 28 | at | Middle Tenn State | 6 | SEC | ||
| 9/9/2017 | Middle Tenn State | 30 | at | Syracuse (4-8) | 23 | at ACC | ||
| 9/16/2017 | Middle Tenn State | 3 | at | Minnesota (5-7) | 34 | at B10 | ||
| 9/23/2017 | Bowling Green (2-10) | 13 | at | Middle Tenn State | 24 | MAC | ||
| 9/30/2017 | Middle Tenn State | 20 | at | Florida Atlantic (11-3,9-0) | 38 | |||
| 10/7/2017 | Florida Intl (8-5,5-3) | 17 | at | Middle Tenn State | 37 | |||
| 10/14/2017 | Middle Tenn State | 23 | at | UAB (8-5,6-2) | 25 | |||
| 10/20/2017 | Marshall (8-5,4-4) | 38 | at | Middle Tenn State | 10 | |||
| 11/4/2017 | UTEP (0-12,0-8) | 3 | at | Middle Tenn State | 30 | |||
| 11/11/2017 | Middle Tenn State | 35 | at | UNC-Charlotte (1-11,1-7) | 21 | |||
| 11/17/2017 | Middle Tenn State | 38 | at | Western Kentucky (6-7,4-4) | 41 | |||
| 11/25/2017 | Old Dominion (5-7,3-5) | 10 | at | Middle Tenn State | 41 | |||
| 12/16/2017 | Middle Tenn State | 35 | vs | Arkansas State (7-5) | 30 | Camelia Bowl (Montgomery AL) | vs SBC |
| vs Middle Tenn State | vs Other Opponents | Middle Tenn State compared to OOs | |
| Record: | 6-7 | 64-85 | |
| Points Scored: | 24.69 | 25.67 | 0.98 |
| Points Allowed: | 25.54 | 28.94 | -3.40 |
| Margin: | -0.85 | -3.27 | -2.42 |
| Total Points: | 50.23 | 54.61 | -4.38 |