| 8/31/2017 | Buffalo | 7 | at | Minnesota (5-7) | 17 | at B10 | ||
| 9/9/2017 | Buffalo | 17 | at | Army (10-3) | 21 | at Ind | ||
| 9/16/2017 | Colgate (7-4) | 10 | at | Buffalo | 33 | Pat (1AA) | ||
| 9/23/2017 | Florida Atlantic (11-3) | 31 | at | Buffalo | 34 | CUSA | ||
| 9/30/2017 | Buffalo | 27 | at | Kent State (2-10,1-7) | 13 | |||
| 10/7/2017 | Western Michigan (6-6,4-4) | 71 | at | Buffalo | 68 | 7OT | ||
| 10/14/2017 | Northern Illinois (8-5,6-2) | 14 | at | Buffalo | 13 | |||
| 10/21/2017 | Buffalo | 14 | at | Miami-Ohio (5-7,4-4) | 24 | |||
| 10/28/2017 | Buffalo | 20 | at | Akron (7-7,6-3) | 21 | |||
| 11/7/2017 | Bowling Green (2-10,2-6) | 28 | at | Buffalo | 38 | |||
| 11/16/2017 | Buffalo | 40 | at | Ball State (2-10,0-8) | 24 | |||
| 11/24/2017 | Ohio (9-4,5-3) | 24 | at | Buffalo | 31 |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 6-6 | 68-70 | |
| Points Scored: | 24.83 | 27.57 | 2.74 |
| Points Allowed: | 28.50 | 26.98 | 1.52 |
| Margin: | -3.67 | 0.59 | 4.26 |
| Total Points: | 53.33 | 54.55 | -1.22 |