| 9/2/2017 | Charleston Southern | 0 | at | Mississippi State (9-4) | 49 | at SEC | ||
| 9/9/2017 | Charleston Southern | at | South Carolina State (3-7) | Postponed WX | at MEAC | |||
| 9/16/2017 | Charleston Southern | 17 | at | Elon (8-4) | 19 | at CAAF | ||
| 9/23/2017 | Point (3-8) | 0 | at | Charleston Southern | 66 | MSC (NAIA) | ||
| 9/30/2017 | Mississippi Valley State (2-9) | 7 | at | Charleston Southern | 58 | SWAC | ||
| 10/7/2017 | Charleston Southern | 0 | at | Indiana (5-7) | 27 | at B10 | ||
| 10/14/2017 | Charleston Southern | 7 | at | Presbyterian (4-7,1-4) | 0 | |||
| 10/21/2017 | Savannah State (3-8) | 27 | at | Charleston Southern | 52 | MEAC | ||
| 10/28/2017 | Monmouth NJ (9-3,4-1) | 23 | at | Charleston Southern | 20 | |||
| 11/4/2017 | Charleston Southern | 10 | at | Gardner-Webb (1-10,0-5) | 9 | |||
| 11/11/2017 | Charleston Southern | 0 | at | Kennesaw St (12-2,5-0) | 38 | |||
| 11/18/2017 | Liberty (6-5,2-3) | 19 | at | Charleston Southern | 20 |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 5-6 | 60-68 | |
| Points Scored: | 19.82 | 24.55 | 4.73 |
| Points Allowed: | 22.73 | 27.90 | -5.17 |
| Margin: | -2.91 | -3.35 | -0.44 |
| Total Points: | 42.55 | 52.45 | -9.90 |