| 9/2/2017 | Louisville | 35 | vs | Purdue (7-6) | 28 | Indianapolis IN | vs B10 | |
| 9/9/2017 | Louisville | 47 | at | North Carolina (3-9,1-7) | 35 | |||
| 9/16/2017 | Clemson (12-2,8-1) | 47 | at | Louisville | 21 | |||
| 9/23/2017 | Kent State (2-10) | 3 | at | Louisville | 42 | MAC | ||
| 9/30/2017 | Murray State (3-8) | 10 | at | Louisville | 55 | OVC (1AA) | ||
| 10/5/2017 | Louisville | 25 | at | North Carolina State (9-4,6-2) | 39 | |||
| 10/14/2017 | Boston College (7-6,4-4) | 45 | at | Louisville | 42 | |||
| 10/21/2017 | Louisville | 31 | at | Florida State (7-6,3-5) | 28 | |||
| 10/28/2017 | Louisville | 32 | at | Wake Forest (8-5,4-4) | 42 | |||
| 11/11/2017 | Virginia (6-7,3-5) | 21 | at | Louisville | 38 | |||
| 11/18/2017 | Syracuse (4-8,2-6) | 10 | at | Louisville | 56 | |||
| 11/25/2017 | Louisville | 44 | at | Kentucky (7-6) | 17 | at SEC | ||
| 12/30/2017 | Louisville | 27 | vs | Mississippi State (9-4) | 31 | Taxslayer Bowl (Jacksonville FL) | vs SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 5-8 | 79-73 | |
| Points Scored: | 27.38 | 26.84 | -0.54 |
| Points Allowed: | 38.08 | 24.63 | 13.45 |
| Margin: | -10.70 | 2.21 | 12.91 |
| Total Points: | 65.46 | 51.47 | 13.99 |