| 9/3/2015 | Alcorn State | 6 | at | Georgia Tech | 69 | SWAC (1AA) | ||
| North Carolina | 13 | vs | South Carolina | 17 | Charlotte NC | vs SEC | ||
| Duke | 37 | at | Tulane | 7 | @ AAC | |||
| Elon | 3 | at | Wake Forest | 41 | CAAF (1AA) | |||
| 9/4/2015 | Rhode Island | 0 | at | Syracuse | 47 | CAAF (1AA) | ||
| 9/5/2015 | Louisville | 24 | vs | Auburn | 31 | Atlanta GA | vs SEC | |
| Maine | 3 | at | Boston College | 24 | CAAF (1AA) | |||
| Wofford | 10 | at | Clemson | 49 | SoCon (1AA) | |||
| Texas State | 16 | at | Florida State | 59 | SBC | |||
| Bethune-Cookman | 0 | at | Miami-Florida | 45 | MEAC (1AA) | |||
| Troy | 21 | at | North Carolina State | 49 | SBC | |||
| Youngstown State | 37 | at | Pittsburgh | 45 | MVC (1AA) | |||
| Virginia | 16 | at | UCLA | 34 | @ P12 | |||
| 9/7/2015 | Ohio State | 42 | at | Virginia Tech | 24 | B10 | ||
| 9/11/2015 | Miami-Florida | 44 | at | Florida Atlantic | 20 | @ CUSA | ||
| 9/12/2015 | Pittsburgh | 24 | at | Akron | 7 | @ MAC | ||
| Howard | 0 | at | Boston College | 76 | MEAC (1AA) | |||
| Appalachian State | 10 | at | Clemson | 41 | SBC | |||
| North Carolina Central | 0 | at | Duke | 55 | MEAC (1AA) | |||
| South Florida | 14 | at | Florida State | 34 | AAC | |||
| Tulane | 10 | at | Georgia Tech | 65 | AAC | |||
| Houston | 34 | at | Louisville | 31 | AAC | |||
| North Carolina A&T | 14 | at | North Carolina | 53 | MEAC (1AA) | |||
| Eastern Kentucky | 0 | at | North Carolina State | 35 | OVC (1AA) | |||
| Wake Forest | 17 | at | Syracuse | 30 | ||||
| Notre Dame | 34 | at | Virginia | 27 | ND | |||
| Furman | 3 | at | Virginia Tech | 42 | SoCon (1AA) | |||
| 9/17/2015 | Clemson | 20 | at | Louisville | 17 | |||
| 9/18/2015 | Florida State | 14 | at | Boston College | 0 | |||
| 9/19/2015 | Wake Forest | 17 | at | Army | 14 | @ Ind | ||
| Northwestern | 19 | at | Duke | 10 | B10 | |||
| Pittsburgh | 24 | at | Iowa | 27 | @ B10 | |||
| Nebraska | 33 | at | Miami-Florida | 36 | OT | B10 | ||
| Illinois | 14 | at | North Carolina | 48 | B10 | |||
| Georgia Tech | 22 | at | Notre Dame | 30 | @ ND | |||
| North Carolina State | 38 | at | Old Dominion | 14 | @ CUSA | |||
| Virginia Tech | 51 | at | Purdue | 24 | @ B10 | |||
| Central Michigan | 27 | at | Syracuse | 30 | OT | MAC | ||
| William & Mary | 29 | at | Virginia | 35 | CAAF (1AA) | |||
| 9/25/2015 | Boise State | 56 | at | Virginia | 14 | MW | ||
| 9/26/2015 | Northern Illinois | 14 | at | Boston College | 17 | MAC | ||
| Georgia Tech | 20 | at | Duke | 34 | ||||
| Virginia Tech | 28 | at | East Carolina | 35 | @ AAC | |||
| Samford | 3 | at | Louisville | 45 | SoCon (1AA) | |||
| Delaware | 14 | at | North Carolina | 41 | CAAF (1AA) | |||
| North Carolina State | 63 | at | South Alabama | 13 | @ SBC | |||
| LSU | 34 | at | Syracuse | 24 | SEC | |||
| Indiana | 31 | at | Wake Forest | 24 | B10 | |||
| 10/1/2015 | Miami-Florida | 23 | at | Cincinnati | 34 | @ AAC | ||
| 10/3/2015 | Notre Dame | 22 | at | Clemson | 24 | ND | ||
| Boston College | 7 | at | Duke | 9 | ||||
| North Carolina | 38 | at | Georgia Tech | 31 | ||||
| Louisville | 20 | at | North Carolina State | 13 | ||||
| Pittsburgh | 17 | at | Virginia Tech | 13 | ||||
| Florida State | 24 | at | Wake Forest | 16 | ||||
| 10/9/2015 | North Carolina State | 13 | at | Virginia Tech | 28 | |||
| 10/10/2015 | Duke | 44 | at | Army | 3 | @ Ind | ||
| Wake Forest | 3 | at | Boston College | 0 | ||||
| Georgia Tech | 24 | at | Clemson | 43 | ||||
| Miami-Florida | 24 | at | Florida State | 29 | ||||
| Virginia | 19 | at | Pittsburgh | 26 | ||||
| Syracuse | 24 | at | South Florida | 45 | @ AAC | |||
| 10/17/2015 | Boston College | 17 | at | Clemson | 34 | |||
| Louisville | 21 | at | Florida State | 41 | ||||
| Pittsburgh | 31 | at | Georgia Tech | 28 | ||||
| Virginia Tech | 20 | at | Miami-Florida | 30 | ||||
| Wake Forest | 14 | at | North Carolina | 50 | ||||
| Syracuse | 38 | at | Virginia | 44 | 3OT | |||
| 10/24/2015 | Florida State | 16 | at | Georgia Tech | 22 | |||
| Boston College | 14 | at | Louisville | 17 | ||||
| Clemson | 58 | at | Miami-Florida | 0 | ||||
| Virginia | 13 | at | North Carolina | 26 | ||||
| Pittsburgh | 23 | at | Syracuse | 20 | ||||
| Duke | 45 | at | Virginia Tech | 43 | 2OT | |||
| North Carolina State | 35 | at | Wake Forest | 17 | ||||
| 10/29/2015 | North Carolina | 26 | at | Pittsburgh | 19 | |||
| 10/30/2015 | Louisville | 20 | at | Wake Forest | 19 | |||
| 10/31/2015 | Virginia Tech | 26 | at | Boston College | 10 | |||
| Miami-Florida | 30 | at | Duke | 27 | ||||
| Syracuse | 21 | at | Florida State | 45 | ||||
| Clemson | 56 | at | North Carolina State | 41 | ||||
| Georgia Tech | 21 | at | Virginia | 27 | ||||
| 11/7/2015 | North Carolina State | 24 | at | Boston College | 8 | |||
| Florida State | 13 | at | Clemson | 23 | ||||
| Syracuse | 17 | at | Louisville | 41 | ||||
| Virginia | 21 | at | Miami-Florida | 27 | ||||
| Duke | 31 | at | North Carolina | 66 | ||||
| Notre Dame | 42 | at | Pittsburgh | 30 | ND | |||
| 11/12/2015 | Virginia Tech | 23 | at | Georgia Tech | 21 | |||
| 11/14/2015 | Pittsburgh | 31 | at | Duke | 13 | |||
| North Carolina State | 17 | at | Florida State | 34 | ||||
| Virginia | 31 | at | Louisville | 38 | ||||
| Miami-Florida | 21 | at | North Carolina | 59 | ||||
| Wake Forest | 7 | at | Notre Dame | 28 | @ ND | |||
| Clemson | 37 | at | Syracuse | 27 | ||||
| 11/21/2015 | Notre Dame | 19 | vs | Boston College | 16 | Boston MA | vs ND | |
| Wake Forest | 13 | at | Clemson | 33 | ||||
| Chattanooga | 13 | at | Florida State | 52 | SoCon (1AA) | |||
| Georgia Tech | 21 | at | Miami-Florida | 38 | ||||
| Syracuse | 29 | at | North Carolina State | 42 | ||||
| Louisville | 34 | at | Pittsburgh | 45 | ||||
| Duke | 34 | at | Virginia | 42 | ||||
| North Carolina | 30 | at | Virginia Tech | 27 | OT | |||
| 11/27/2015 | Miami-Florida | 29 | at | Pittsburgh | 24 | |||
| 11/28/2015 | Florida State | 27 | at | Florida | 2 | @ SEC | ||
| Georgia | 13 | at | Georgia Tech | 7 | SEC | |||
| Louisville | 38 | at | Kentucky | 24 | @ SEC | |||
| North Carolina | 45 | at | North Carolina State | 34 | ||||
| Clemson | 37 | at | South Carolina | 32 | @ SEC | |||
| Boston College | 17 | at | Syracuse | 20 | ||||
| Virginia Tech | 23 | at | Virginia | 20 | ||||
| Duke | 27 | at | Wake Forest | 21 | ||||
| 12/5/2015 | North Carolina | 37 | vs | Clemson | 45 | ACC Championship (Charlotte NC) | ||
| 12/26/2015 | Indiana | 41 | vs | Duke | 44 | OT | Pinstripe Bowl (New York NY) | vs B10 |
| Tulsa | 52 | vs | Virginia Tech | 55 | Independence Bowl (Shrevepoint LA) | vs AAC | ||
| Miami-Florida | 14 | vs | Washington State | 20 | Sun Bowl (El Paso TX) | vs P12 | ||
| 12/28/2015 | Pittsburgh | 28 | vs | Navy | 44 | Military Bowl (Annapolis MD) | vs AAC | |
| 12/29/2015 | North Carolina | 38 | vs | Baylor | 49 | Russell Athletic Bowl (Orlando FL) | vs B12 | |
| 12/30/2015 | Texas A&M | 21 | vs | Louisville | 27 | Music City Bowl (Nashville TN) | vs SEC | |
| North Carolina State | 28 | vs | Mississippi State | 51 | Belk Bowl (Charlotte NC) | vs SEC | ||
| 12/31/2015 | Oklahoma | 17 | vs | Clemson | 37 | Orange Bowl (Miami FL) | vs B12 | |
| Florida State | 24 | vs | Houston | 38 | Peach Bowl (Atlanta GA) | vs AAC | ||
| 1/11/2016 | Alabama | 45 | vs | Clemson | 40 | CFP National Championship | vs SEC |