| 9/5/2015 | Akron (8-5) | 3 | at | Oklahoma | 41 | MAC | ||
| 9/12/2015 | Oklahoma | 31 | at | Tennessee (9-4) | 24 | 2OT | at SEC | |
| 9/19/2015 | Tulsa (6-7) | 38 | at | Oklahoma | 52 | AAC | ||
| 10/3/2015 | West Virginia (8-5,4-5) | 24 | at | Oklahoma | 44 | |||
| 10/10/2015 | Oklahoma | 17 | vs | Texas (5-7,4-5) | 24 | Dallas TX | ||
| 10/17/2015 | Oklahoma | 55 | at | Kansas State (6-7,3-6) | 0 | |||
| 10/24/2015 | Texas Tech (7-6,4-5) | 27 | at | Oklahoma | 63 | |||
| 10/31/2015 | Oklahoma | 62 | at | Kansas (0-12,0-9) | 7 | |||
| 11/7/2015 | Iowa State (3-9,2-7) | 16 | at | Oklahoma | 52 | |||
| 11/14/2015 | Oklahoma | 44 | at | Baylor (10-3,6-3) | 34 | |||
| 11/21/2015 | TCU (11-2,7-2) | 29 | at | Oklahoma | 30 | |||
| 11/28/2015 | Oklahoma | 58 | at | Oklahoma State (10-3,7-2) | 23 | |||
| 12/31/2015 | Oklahoma | 17 | vs | Clemson (14-1) | 37 | Orange Bowl (Miami FL) | vs ACC |
| vs Oklahoma | vs Other Opponents | Oklahoma compared to OOs | |
| Record: | 2-11 | 95-60 | |
| Points Scored: | 22.00 | 35.08 | 13.08 |
| Points Allowed: | 43.54 | 29.24 | 14.30 |
| Margin: | -21.54 | 5.84 | 27.38 |
| Total Points: | 65.54 | 64.32 | 1.22 |