| 9/6/2015 | Purdue | 31 | at | Marshall (10-3) | 41 | at CUSA | ||
| 9/12/2015 | Indiana State (5-6) | 14 | at | Purdue | 38 | MVC (1AA) | ||
| 9/19/2015 | Virginia Tech (7-6) | 51 | at | Purdue | 24 | ACC | ||
| 9/26/2015 | Bowling Green (10-4) | 35 | at | Purdue | 28 | MAC | ||
| 10/3/2015 | Purdue | 21 | at | Michigan State (12-2,8-1) | 24 | |||
| 10/10/2015 | Minnesota (6-7,2-6) | 41 | at | Purdue | 13 | |||
| 10/17/2015 | Purdue | 7 | at | Wisconsin (10-3,6-2) | 24 | |||
| 10/31/2015 | Nebraska (6-7,3-5) | 45 | at | Purdue | 55 | |||
| 11/7/2015 | Illinois (5-7,2-6) | 48 | at | Purdue | 14 | |||
| 11/14/2015 | Purdue | 14 | at | Northwestern (10-3,6-2) | 21 | |||
| 11/21/2015 | Purdue | 20 | at | Iowa (12-2,8-1) | 40 | |||
| 11/28/2015 | Indiana (6-7,2-6) | 54 | at | Purdue | 36 |
| vs Purdue | vs Other Opponents | Purdue compared to OOs | |
| Record: | 10-2 | 89-55 | |
| Points Scored: | 36.50 | 29.07 | -7.43 |
| Points Allowed: | 25.08 | 24.23 | 0.85 |
| Margin: | 11.42 | 4.84 | -6.58 |
| Total Points: | 61.58 | 53.30 | 8.28 |