| 9/3/2015 | Valparaiso (1-9) | 10 | at | Eastern Kentucky | 52 | Pio | ||
| 9/12/2015 | Eastern Kentucky | 0 | at | North Carolina State (7-6) | 35 | at ACC | ||
| 9/26/2015 | Austin Peay (0-11,0-8) | 13 | at | Eastern Kentucky | 51 | |||
| 10/3/2015 | Eastern Kentucky | 27 | at | Kentucky (5-7) | 34 | OT | at SEC | |
| 10/8/2015 | Tennessee Tech (4-7,3-5) | 17 | at | Eastern Kentucky | 48 | Georgetown KY | ||
| 10/17/2015 | Eastern Kentucky | 27 | at | SE Missouri State (4-7,3-4) | 10 | |||
| 10/24/2015 | Tennessee State (4-6,1-6) | 21 | at | Eastern Kentucky | 45 | |||
| 10/31/2015 | Eastern Kentucky | 0 | at | Jacksonville State (13-2,8-0) | 34 | |||
| 11/7/2015 | Tennessee-Martin (7-4,6-2) | 42 | at | Eastern Kentucky | 35 | |||
| 11/14/2015 | Eastern Kentucky | 41 | at | Murray State (3-8,2-6) | 34 | 2OT | ||
| 11/21/2015 | Eastern Kentucky | 7 | at | Eastern Illinois (7-5,7-1) | 21 |
| vs Eastern Kentucky | vs Other Opponents | Eastern Kentucky compared to OOs | |
| Record: | 5-6 | 50-66 | |
| Points Scored: | 24.64 | 26.91 | 2.27 |
| Points Allowed: | 30.27 | 30.73 | -0.46 |
| Margin: | -5.63 | -3.82 | 1.81 |
| Total Points: | 54.91 | 57.64 | -2.73 |