| 9/5/2015 | Howard (1-11) | 0 | at | Appalachian State | 49 | MEAC (1AA) | ||
| 9/12/2015 | Appalachian State | 10 | at | Clemson (14-1) | 41 | at ACC | ||
| 9/26/2015 | Appalachian State | 49 | at | Old Dominion (5-7) | 0 | at CUSA | ||
| 10/3/2015 | Wyoming (2-10) | 13 | at | Appalachian State | 31 | MW | ||
| 10/10/2015 | Appalachian State | 37 | at | Georgia State (6-7,5-3) | 3 | |||
| 10/17/2015 | Appalachian State | 59 | at | UL Monroe (2-11,1-7) | 14 | |||
| 10/22/2015 | Georgia Southern (9-4,6-2) | 13 | at | Appalachian State | 31 | |||
| 10/31/2015 | Troy (4-8,3-5) | 41 | at | Appalachian State | 44 | 3OT | ||
| 11/5/2015 | Arkansas State (9-4,8-0) | 40 | at | Appalachian State | 27 | |||
| 11/14/2015 | Appalachian State | 47 | at | Idaho (4-8,3-5) | 20 | |||
| 11/28/2015 | UL Lafayette (4-8,3-5) | 7 | at | Appalachian State | 28 | |||
| 12/5/2015 | Appalachian State | 34 | at | South Alabama (5-7,3-5) | 27 | |||
| 12/19/2015 | Ohio (8-5) | 29 | vs | Appalachian State | 31 | Camellia Bowl (Montgomery AL) | MAC |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 2-11 | 71-80 | |
| Points Scored: | 19.08 | 28.57 | 9.49 |
| Points Allowed: | 36.69 | 30.98 | 5.71 |
| Margin: | -17.61 | -2.41 | 15.20 |
| Total Points: | 55.77 | 59.55 | -3.78 |