| 9/5/2015 | Stanford (12-2) | 6 | at | Northwestern | 16 | P12 | ||
| 9/12/2015 | Eastern Illinois (7-5) | 0 | at | Northwestern | 41 | OVC (1AA) | ||
| 9/19/2015 | Northwestern | 19 | at | Duke (8-5) | 10 | at ACC | ||
| 9/26/2015 | Ball State (3-9) | 19 | at | Northwestern | 24 | MAC | ||
| 10/3/2015 | Minnesota (6-7,2-6) | 0 | at | Northwestern | 27 | |||
| 10/10/2015 | Northwestern | 0 | at | Michigan (10-3,6-2) | 38 | |||
| 10/17/2015 | Iowa (12-2,8-1) | 40 | at | Northwestern | 10 | |||
| 10/24/2015 | Northwestern | 30 | at | Nebraska (6-7,3-5) | 28 | |||
| 11/7/2015 | Penn State (7-6,4-4) | 21 | at | Northwestern | 23 | |||
| 11/14/2015 | Purdue (2-10,1-7) | 14 | at | Northwestern | 21 | |||
| 11/21/2015 | Northwestern | 13 | at | Wisconsin (10-3,6-2) | 7 | |||
| 11/28/2015 | Northwestern | 24 | vs | Illinois (5-7,2-6) | 14 | Chicago IL | ||
| 1/1/2016 | Northwestern | 6 | vs | Tennessee (9-4) | 45 | Outback Bowl (Tampa FL) | vs SEC |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 3-10 | 94-60 | |
| Points Scored: | 18.62 | 29.19 | 10.57 |
| Points Allowed: | 19.54 | 24.46 | -4.92 |
| Margin: | -0.92 | 4.73 | 5.65 |
| Total Points: | 38.16 | 53.65 | -15.49 |