| 9/5/2015 | Gardner-Webb (4-7) | 23 | at | South Alabama | 33 | BigS (1AA) | ||
| 9/12/2015 | South Alabama | 9 | at | Nebraska (6-7) | 48 | at B10 | ||
| 9/19/2015 | South Alabama | 34 | at | San Diego State (11-3) | 27 | at MW | ||
| 9/26/2015 | North Carolina State (7-6) | 63 | at | South Alabama | 13 | ACC | ||
| 10/3/2015 | South Alabama | 24 | at | Troy (4-8,3-5) | 18 | |||
| 10/13/2015 | Arkansas State (9-4,8-0) | 49 | at | South Alabama | 31 | |||
| 10/24/2015 | South Alabama | 18 | at | Texas State (3-9,2-6) | 36 | |||
| 11/7/2015 | Idaho (4-8,3-5) | 45 | at | South Alabama | 52 | |||
| 11/12/2015 | UL Lafayette (4-8,3-5) | 25 | at | South Alabama | 32 | |||
| 11/21/2015 | South Alabama | 10 | at | Georgia State (6-7,5-3) | 24 | |||
| 11/28/2015 | South Alabama | 17 | at | Georgia Southern (9-4,6-2) | 55 | |||
| 12/5/2015 | Appalachian State (11-2,7-1) | 34 | at | South Alabama | 27 |
| vs South Alabama | vs Other Opponents | South Alabama compared to OOs | |
| Record: | 7-5 | 71-68 | |
| Points Scored: | 37.25 | 29.95 | -7.30 |
| Points Allowed: | 25.00 | 27.82 | -2.82 |
| Margin: | 12.25 | 2.13 | -10.12 |
| Total Points: | 62.25 | 57.77 | 4.48 |