| 9/5/2015 | Florida A&M (1-10) | 3 | at | South Florida | 51 | MEAC (1AA) | ||
| 9/12/2015 | South Florida | 14 | at | Florida State (10-3) | 34 | at ACC | ||
| 9/19/2015 | South Florida | 17 | at | Maryland (3-9) | 35 | at B10 | ||
| 10/2/2015 | Memphis (9-4,5-3) | 24 | at | South Florida | 17 | |||
| 10/10/2015 | Syracuse (4-8) | 24 | at | South Florida | 45 | ACC | ||
| 10/17/2015 | South Florida | 28 | at | Connecticut (6-7,4-4) | 20 | |||
| 10/24/2015 | SMU (2-10,1-7) | 14 | at | South Florida | 38 | |||
| 10/31/2015 | South Florida | 17 | at | Navy (11-2,7-1) | 29 | |||
| 11/7/2015 | South Florida | 22 | at | East Carolina (5-7,3-5) | 17 | |||
| 11/14/2015 | Temple (10-4,7-2) | 23 | at | South Florida | 44 | |||
| 11/20/2015 | Cincinnati (7-6,4-4) | 27 | at | South Florida | 65 | |||
| 11/26/2015 | South Florida | 44 | at | UCF (0-12,0-8) | 3 | |||
| 12/21/2015 | Western Kentucky (12-2) | 45 | vs | South Florida | 35 | Miami Beach Bowl (Miami FL) | CUSA |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 5-8 | 75-76 | |
| Points Scored: | 22.92 | 29.32 | 6.40 |
| Points Allowed: | 33.62 | 27.79 | 5.83 |
| Margin: | -10.70 | 1.53 | 12.23 |
| Total Points: | 56.54 | 57.11 | -0.57 |