| 9/5/2015 | Tennessee Tech (4-7) | 24 | at | Houston | 52 | OVC (1AA) | ||
| 9/12/2015 | Houston | 34 | at | Louisville (8-5) | 31 | at ACC | ||
| 9/26/2015 | Texas State (3-9) | 14 | at | Houston | 59 | SBC | ||
| 10/3/2015 | Houston | 38 | at | Tulsa (6-7,3-5) | 24 | |||
| 10/8/2015 | SMU (2-10,1-7) | 28 | at | Houston | 49 | |||
| 10/16/2015 | Houston | 42 | at | Tulane (3-9,1-7) | 7 | |||
| 10/24/2015 | Houston | 59 | at | UCF (0-12,0-8) | 10 | |||
| 10/31/2015 | Vanderbilt (4-8) | 0 | at | Houston | 34 | SEC | ||
| 11/7/2015 | Cincinnati (7-6,4-4) | 30 | at | Houston | 33 | |||
| 11/14/2015 | Memphis (9-4,5-3) | 34 | at | Houston | 35 | |||
| 11/21/2015 | Houston | 17 | at | Connecticut (6-7,4-4) | 20 | |||
| 11/27/2015 | Navy (11-2,7-1) | 31 | at | Houston | 52 | |||
| 12/5/2015 | Temple (10-4,7-2) | 13 | at | Houston | 24 | AAC Championship | ||
| 12/31/2015 | Florida State (10-3) | 24 | vs | Houston | 38 | Peach Bowl (Atlanta GA) | ACC |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 1-13 | 82-80 | |
| Points Scored: | 20.71 | 28.11 | 7.40 |
| Points Allowed: | 40.43 | 28.52 | 11.91 |
| Margin: | -19.72 | -0.41 | 19.31 |
| Total Points: | 61.14 | 56.63 | 4.51 |