| 9/7/2015 | Ohio State | 42 | at | Virginia Tech (7-6) | 24 | at ACC | ||
| 9/12/2015 | Hawaii (3-10) | 0 | at | Ohio State | 38 | MW | ||
| 9/19/2015 | Northern Illinois (8-6) | 13 | at | Ohio State | 20 | MAC | ||
| 9/26/2015 | Western Michigan (8-5) | 12 | at | Ohio State | 38 | MAC | ||
| 10/3/2015 | Ohio State | 34 | at | Indiana (6-7,2-6) | 27 | |||
| 10/10/2015 | Maryland (3-9,1-7) | 28 | at | Ohio State | 49 | |||
| 10/17/2015 | Penn State (7-6,4-4) | 10 | at | Ohio State | 38 | |||
| 10/24/2015 | Ohio State | 49 | at | Rutgers (4-8,1-7) | 7 | |||
| 11/7/2015 | Minnesota (6-7,2-6) | 14 | at | Ohio State | 28 | |||
| 11/14/2015 | Ohio State | 28 | at | Illinois (5-7,2-6) | 3 | |||
| 11/21/2015 | Michigan State (12-2,8-1) | 17 | at | Ohio State | 14 | |||
| 11/28/2015 | Ohio State | 42 | at | Michigan (10-3,6-2) | 13 | |||
| 1/1/2016 | Notre Dame (10-3) | 28 | vs | Ohio State | 44 | Fiesta Bowl (Glendale AZ) | ND |
| vs Ohio State | vs Other Opponents | Ohio State compared to OOs | |
| Record: | 1-12 | 88-67 | |
| Points Scored: | 15.08 | 29.49 | 14.41 |
| Points Allowed: | 35.69 | 26.69 | 9.00 |
| Margin: | -20.61 | 2.80 | 23.41 |
| Total Points: | 50.77 | 56.18 | -5.41 |