| 9/5/2015 | Towson (7-4) | 20 | at | East Carolina | 28 | CAAF (1AA) | ||
| 9/12/2015 | East Carolina | 24 | at | Florida (10-4) | 31 | at SEC | ||
| 9/19/2015 | East Carolina | 21 | at | Navy (11-2,7-1) | 45 | |||
| 9/26/2015 | Virginia Tech (7-6) | 28 | at | East Carolina | 35 | ACC | ||
| 10/3/2015 | East Carolina | 49 | at | SMU (2-10,1-7) | 23 | |||
| 10/10/2015 | East Carolina | 38 | at | BYU (9-4) | 45 | at Ind | ||
| 10/17/2015 | Tulsa (6-7,3-5) | 17 | at | East Carolina | 30 | |||
| 10/22/2015 | Temple (10-4,7-2) | 24 | at | East Carolina | 14 | |||
| 10/30/2015 | East Carolina | 13 | at | Connecticut (6-7,4-4) | 31 | |||
| 11/7/2015 | South Florida (8-5,6-2) | 22 | at | East Carolina | 17 | |||
| 11/19/2015 | East Carolina | 44 | at | UCF (0-12,0-8) | 7 | |||
| 11/28/2015 | Cincinnati (7-6,4-4) | 19 | at | East Carolina | 16 |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 7-5 | 76-66 | |
| Points Scored: | 26.00 | 28.82 | 2.82 |
| Points Allowed: | 27.42 | 27.05 | 0.37 |
| Margin: | -1.42 | 1.77 | 3.19 |
| Total Points: | 53.42 | 55.87 | -2.45 |